HLA-A33

HLA-A33
HLA-A33
(MHC Class I, A cell surface antigen)
	HLA-A33
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-A*33--, β2-microglobulin
Subtypes
Subtype
Subtype	allele
A33	*3301
A33.3	*3303
{{{cNick3}}}	*33{{{cAllele3}}}
{{{cNick4}}}	*33{{{cAllele4}}}
	Alleles link-out to IMGT/HLA database at EBI

HLA-A33 (A33) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α³³ subset of HLA-A α-chains. For A33, the alpha "A" chain are encoded by the HLA-A*33 allele group and the β-chain are encoded by B2M locus.^[1] A33 and A*33 are almost synonymous in meaning. A33 is a split antigen of the broad antigen serotype A19. A33 is a sister serotype of A29, A30, A31, A32, and A74.

A33 is more common in Subsaharan Africa.

Serotype

A33 recognition of some HLA A*33 gene products^[2]
A*33	A33	A19	Sample
allele	%	%	size (N)
*3301	87	3	687
*3303	95	0	807

A33 has a poor serotyping rate.

^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
^ Allele Query Form IMGT/HLA - European Bioinformatics Institute

[pmid77067-1] Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.

[2] Allele Query Form IMGT/HLA - European Bioinformatics Institute

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