HLA-A34

HLA-A34
HLA-A34
(MHC Class I, A cell surface antigen)
	HLA-A34
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-A*34--, β2-microglobulin
Older names	A10
Subtypes
Subtype
Subtype	allele
A34.1	*3401
A34.2	*3402
{{{cNick3}}}	*34{{{cAllele3}}}
{{{cNick4}}}	*34{{{cAllele4}}}
	Alleles link-out to IMGT/HLA database at EBI

HLA-A34 (A34) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α³⁴ subset of HLA-A α-chains. For A34, the alpha "A" chain are encoded by the HLA-A*34 allele group and the β-chain are encoded by B2M locus.^[1] A34 and A*34 are almost synonymous in meaning. A34 is a split antigen of the broad antigen serotype A10. A34 is a sister serotype of A25, A26, A43, and A66.

A34 is most similar to A66.

Serotype

A34 recognition of some HLA A*34 gene products^[2]
A*34	A34	A10	Sample
allele	%	%	size (N)
*3401	67	5	269
*3402	89	2	996

A34 serotyping is modest.

^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
^ Allele Query Form IMGT/HLA - European Bioinformatics Institute

[pmid77067-1] Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.

[2] Allele Query Form IMGT/HLA - European Bioinformatics Institute

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