HLA-A36

HLA-A36
(MHC Class I, A cell surface antigen)
HLA-A36
About
Proteintransmembrane receptor/ligand
Structureαβ heterodimer
SubunitsHLA-A*3601, β2-microglobulin
Subtypes
Subtype
allele
Available structures
A36 *3601
{{{cNick2}}} *36{{{cAllele2}}}
{{{cNick3}}} *36{{{cAllele3}}}
{{{cNick4}}} *36{{{cAllele4}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-A36 (A36) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α36 subset of HLA-A α-chains. For A36, the alpha "A" chain are encoded by the HLA-A*36 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*3601. A36 and A*36 are almost synonymous in meaning.

A36 is more common in Africa (North and East) and Central Asia. A36 is rare HLA-A allele group.

Serotype

[edit]
A36 recognition of some HLA A*36 gene products[2]
A*36 A36 A1 Sample
allele % % size (N)
*3601 68 16 807

A36 has a high false serotyping rate to A1.

  1. ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
  2. ^ Allele Query Form IMGT/HLA - European Bioinformatics Institute