HLA-A68

HLA-A68
HLA-A68
(MHC Class I, A cell surface antigen)
	Rendering or 2hla showing A*6801 (cyan) and Beta-2 microglobulin (rose). There is no bound peptide in this image.
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-A*68--, β2-microglobulin
Older names	A28
Subtypes
Subtype
Subtype	allele
Aw68.1	*6801
Aw68.2	*6802
-	*6803
{{{cNick4}}}	*68{{{cAllele4}}}
Rare alleles
Subtype
Subtype	allele
-	*6805
{{{rnick2}}}	*68{{{rallele2}}}
{{{rnick3}}}	*68{{{rallele3}}}
	Alleles link-out to IMGT/HLA database at EBI

HLA-A68 (A68) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α⁶⁸ subset of HLA-A α-chains. For A68, the alpha "A" chain are encoded by the HLA-A*68 allele group and the β-chain are encoded by B2M locus.^[1] A68 and A*68 are almost synonymous in meaning. A68 is a split antigen of the broad antigen serotype A28. A68 is a sister serotype of A69.

A68 is more common in North America.

Serotype

A68 recognition of some HLA A*68 gene products^[2]
A*68	A68	A28	A69	Sample
allele	%	%	%	size (N)
*6801	27	63	0	2736

A68 is poor, with low specific detection, high non-specific identification by A28.

^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
^ Allele Query Form IMGT/HLA - European Bioinformatics Institute

[pmid77067-1] Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.

[2] Allele Query Form IMGT/HLA - European Bioinformatics Institute

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