HLA-A69

HLA-A69
(MHC Class I, A cell surface antigen)
HLA-A69
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-A*69--, β2-microglobulin
Older names	A28
Subtypes
Subtype allele Available structures A69 *6901 {{{cNick2}}} *69{{{cAllele2}}} {{{cNick3}}} *69{{{cAllele3}}} {{{cNick4}}} *69{{{cAllele4}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-A69 (A69) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α⁶⁹ subset of HLA-A α-chains. For A69, the alpha "A" chain are encoded by the HLA-A*69 allele group and the β-chain are encoded by B2M locus.^[1] This group currently is dominated by A*6901. A69 and A*69 are almost synonymous in meaning. A69 is a split antigen of the broad antigen serotype A28. A69 is a sister serotype of A68.

A69 is more common in Levant. A69 (A*6901) is a derivative of the A*6801 allele that has undergone gene conversion with A*02. The recombination took place no more than 330,000 years ago^[2].

A69 is poor, with low specific detection, high non-specific identification by A28, and false recognition by A68 and A2.