HLA-A80

HLA-A80
(MHC Class I, A cell surface antigen)
HLA-A80
About
Proteintransmembrane receptor/ligand
Structureαβ heterodimer
SubunitsHLA-A*8001, β2-microglobulin
Older namesAX"BG"
Subtypes
Subtype
allele
Available structures
A*80 *8001
{{{cNick2}}} *80{{{cAllele2}}}
{{{cNick3}}} *80{{{cAllele3}}}
{{{cNick4}}} *80{{{cAllele4}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-A80 (A80) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α80 subset of HLA-A α-chains. For A80, the alpha "A" chain are encoded by the HLA-A*80 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*8001. A80 and A*80 are almost synonymous in meaning.

A80 is more common in West Central Africa. A80 is the least common HLA-A allele group.

Serotype

[edit]
A80 recognition of some HLA A*80 gene products[2]
A*80 A80 A10 Sample
allele % % size (N)
*8001 36 10 505

A80 HLA-A80 typing is poor. Most typing is done with SSP-PCR. Most of 8001 are detected with "Blank" serotype..

  1. ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
  2. ^ Allele Query Form IMGT/HLA - European Bioinformatics Institute