HLA-B14

Illustration of HLA-B with peptide in the binding pocket.
HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B14
Alleles B*1401, 1402 . .
Structure (See HLA-B)
Shared data
Locus chr.6 6p21.31

HLA-B14 (B14) is a HLA-B serotype. The serotype identifies the B*45 gene-allele protein products of HLA-B.[1]

B14 is a broad antigen composed to two, B64 and B65, split antigens. In the case of B14 the recognition of the broad antigen is more useful than split antigen recognition because of the relatively poor discrimination of the split antigens (see Table below).

  1. ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.