 | This article may be too technical for most readers to understand. (May 2017) |
major histocompatibility complex (human), class I, B48
| ||
| Alleles | B*4801 B*4802 B*4803 | |
| Structure (See HLA-B) | ||
| Symbol(s) | HLA-B | |
| EBI-HLA | B*4801 | |
| EBI-HLA | B*4802 | |
| EBI-HLA | B*4803 | |
| Locus | chr.6 6p21.31 | |
HLA-B48 (B48) is an HLA-B serotype. The serotype identifies the more common HLA-B*48 gene products.[1] B48 is most common along the West Pacific Rim, Americas indigenous peoples and Northern Eurasians. B*4801 is part of a group of alleles including B*4201 that share Intron 1 sequence with B*0702,[2] which is common over Western and Central Asia, and has a distribution indicating an early and long presence in Eurasian humans. A*48 appears to be the result of a recombination event that occurred early in the settlement history of Central Asia that then spread eastward into the NW Pacific rim and the New World. (For terminology help see: HLA-serotype tutorial)
- ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
- ^ Gomez-Casado E, Vargas-Alarcón G, Martinez-Laso J, et al. (1999). "Evolutionary relationships between HLA-B alleles as indicated by an analysis of intron sequences". Tissue Antigens. 53 (2): 153–60. doi:10.1034/j.1399-0039.1999.530205.x. PMID 10090615.