major histocompatibility complex (human), class I, B53
| ||
Alleles | B*5301 B*5302 | |
Structure (See HLA-B) | ||
Symbol(s) | HLA-B | |
EBI-HLA | B*5301 | |
EBI-HLA | B*5302 | |
Locus | chr.6 6p21.31 |
HLA-B53 (B53) is an HLA-B serotype. The serotype identifies the more common HLA-B*53 gene products.[1] The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif (as found in B35), indicating B53 is a recent product of gene conversion.[2] This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence. (For terminology help see: HLA-serotype tutorial)