HLA-B57

Illustration of HLA-B with peptide in the binding pocket.
HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B57
Alleles *5701, *5702, *5703, *5704, *5708[1]
Structure (See HLA-B)
Shared data
Locus chr.6 6p21.31

HLA-B57 (B57) is an HLA-B serotype. B57 is a split antigen from the B17 broad antigen, the sister serotype being B58.[2] The serotype identifies the more common HLA-B*57 gene products.[1] (For terminology help see: HLA-serotype tutorial.) Like B58, B57 is involved in drug-induced inflammatory skin disorders.

  1. ^ a b Marsh SG, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Fernández-Viña M, Geraghty DE, Holdsworth R, Hurley CK, Lau M, Lee KW, Mach B, Maiers M, Mayr WR, Müller CR, Parham P, Petersdorf EW, Sasazuki T, Strominger JL, Svejgaard A, Terasaki PI, Tiercy JM, Trowsdale J (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. ^ Ways JP, Coppin HL, Parham P (1985). "The complete primary structure of HLA-Bw58". J. Biol. Chem. 260 (22): 11924–33. doi:10.1016/S0021-9258(17)38967-6. PMID 2995352.