major histocompatibility complex (human), class I, B7
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Alleles | B*0702, *0703, *0704, *0705 | |
Structure (See HLA-B) | ||
Alleles (See Serotyping) | ||
Locus | chr.6 6p21.31 |
HLA-B7 (B7) is an HLA-B serotype. The serotype identifies the more common HLA-B*07 gene products.[1] (For terminology help see: HLA-serotype tutorial) B7, previously HL-A7, was one of the first 'HL-A' antigens recognized, largely because of the frequency of B*0702 in Northern and Western Europe and the United States. B7 is found in two major haplotypes in Europe, where it reaches peak frequency in Ireland. One haplotype A3-B7-DR15-DQ1 can be found over a vast region and is in apparent selective disequilibrium. B7 is a risk factor for cervical cancer, sarcoidosis, and early-onset spondylarthropathies.[citation needed]