HLA-C

HLA-C
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3BZF,%%s4NT6,%%s1EFX,%%s1IM9, 1QQD
Identifiers
Aliases	HLA-C, D6S204, HLA-JY3, HLC-C, PSORS1, major histocompatibility complex, class I, C, MHC
External IDs	OMIM: 142840; HomoloGene: 133080; GeneCards: HLA-C; OMA:HLA-C - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,268,749 bp[1] End 31,272,130 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood right lung spleen granulocyte right uterine tube appendix bone marrow upper lobe of left lung lymph node bone marrow cells n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptide antigen binding protein binding Cellular component integral component of membrane phagocytic vesicle membrane Golgi apparatus early endosome membrane membrane Golgi membrane plasma membrane cell surface endoplasmic reticulum MHC class I protein complex ER to Golgi transport vesicle membrane integral component of lumenal side of endoplasmic reticulum membrane extracellular exosome secretory granule membrane recycling endosome membrane Biological process antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent immune system process interferon-gamma-mediated signaling pathway antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent type I interferon signaling pathway immune response regulation of immune response viral process neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3107 n/a Ensembl ENSG00000204525 ENSG00000233841 ENSG00000228299 ENSG00000225691 ENSG00000206435 ENSG00000237022 ENSG00000206452 n/a UniProt P10321 n/a RefSeq (mRNA) NM_002117 NM_001243042 n/a RefSeq (protein) NP_001229971 NP_002108 n/a Location (UCSC) Chr 6: 31.27 – 31.27 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

HLA-C (Human Leukocyte Antigen-C) belongs to the MHC class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which surveys for non-self peptides.

HLA-C is a locus on chromosome 6, which encodes for many HLA-C alleles that are Class-I MHC receptors. HLA-C, localized proximal to the HLA-B locus, is located on the distal end of the HLA region. Most HLA-C:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself.