HLA-DMB

HLA-DMB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HDM, 2BC4, 4FQX, 4GBX, 4I0P
Identifiers
Aliases	HLA-DMB, D6S221E, RING7, major histocompatibility complex, class II, DM beta
External IDs	OMIM: 142856; MGI: 95922; HomoloGene: 68231; GeneCards: HLA-DMB; OMA:HLA-DMB - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,941,028 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,379,204 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; lymph node; ; appendix; ; spleen; ; duodenum; ; gallbladder; ; right lung; ; upper lobe of left lung; ; rectum;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; blood; ; right kidney; ; ankle joint; ; superior surface of tongue; ; thymus; ; sciatic nerve; ; lip; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	MHC class II protein complex binding; protein binding;
Cellular component	lysosomal membrane; lysosome; membrane; endosome; late endosome membrane; integral component of membrane; MHC class II protein complex;
Biological process	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; antigen processing and presentation; MHC class II protein complex assembly; positive regulation of T cell proliferation; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; immune system process; antigen processing and presentation of exogenous peptide antigen via MHC class II; immune response; adaptive immune response;
	Sources:Amigo / QuickGO
Orthologs
	3109
	14999
ENSG00000241674; ENSG00000226264; ENSG00000242574; ENSG00000239329; ENSG00000234154;
	ENSG00000242386; ENSG00000242092; ENSG00000241296
	ENSMUSG00000079547
	P28068
	P35737; Q31094
	NM_002118
	NM_010387
	NP_002109
	NP_034517
	Wikidata
View/Edit Human	View/Edit Mouse

HLA class II histocompatibility antigen, DM beta chain is a protein that in humans is encoded by the HLA-DMB gene.^[5]^[6]

^ ^a ^b ^c ENSG00000226264, ENSG00000242574, ENSG00000239329, ENSG00000234154, ENSG00000242386, ENSG00000242092, ENSG00000241296 GRCh38: Ensembl release 89: ENSG00000241674, ENSG00000226264, ENSG00000242574, ENSG00000239329, ENSG00000234154, ENSG00000242386, ENSG00000242092, ENSG00000241296 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079547 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kelly AP, Monaco JJ, Cho SG, Trowsdale J (Nov 1991). "A new human HLA class II-related locus, DM". Nature. 353 (6344): 571–3. Bibcode:1991Natur.353..571K. doi:10.1038/353571a0. PMID 1922365. S2CID 3065226.
^ "Entrez Gene: HLA-DMB major histocompatibility complex, class II, DM beta".

[refGRCh38Ensembl-1] ENSG00000226264, ENSG00000242574, ENSG00000239329, ENSG00000234154, ENSG00000242386, ENSG00000242092, ENSG00000241296 GRCh38: Ensembl release 89: ENSG00000241674, ENSG00000226264, ENSG00000242574, ENSG00000239329, ENSG00000234154, ENSG00000242386, ENSG00000242092, ENSG00000241296 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079547 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1922365-5] Kelly AP, Monaco JJ, Cho SG, Trowsdale J (Nov 1991). "A new human HLA class II-related locus, DM". Nature. 353 (6344): 571–3. Bibcode:1991Natur.353..571K. doi:10.1038/353571a0. PMID 1922365. S2CID 3065226.

[entrez-6] "Entrez Gene: HLA-DMB major histocompatibility complex, class II, DM beta".

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