| MHC class II, DP | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| (heterodimer) | ||||||||||
| Protein type | cell surface receptor | |||||||||
| Function | Immune recognition and antigen presentation | |||||||||
| ||||||||||
HLA-DP is a protein/peptide-antigen receptor and graft-versus-host disease antigen that is composed of 2 subunits, DPα and DPβ. DPα and DPβ are encoded by two loci, HLA-DPA1 and HLA-DPB1, that are found in the MHC Class II (or HLA-D) region in the Human Leukocyte Antigen complex on human chromosome 6 (see protein boxes on right for links). Less is known about HLA-DP relative to HLA-DQ and HLA-DR but the sequencing of DP types and determination of more frequent haplotypes has progressed greatly within the last few years.