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major histocompatibility complex, class II, DQ3
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| Haplotypes | DQA1*0303:DQB1*0301 DQA1*0401:DQB1*0301 DQA1*0505:DQB1*0301 DQA1*0601:DQB1*0301 DQA1*03:DQB1*0302 DQA1*0301:DQB1*0303 |
| Structure (See HLA-DQ) | |
| Identifiers | alpha 1
*0301 *0302 *0303 *0401 *0505 *0601
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| Symbol(s) | HLA-DQA1[permanent dead link] |
| EBI-HLA | DQA1*0301 |
| EBI-HLA | DQA1*0302 |
| EBI-HLA | DQA1*0303 |
| EBI-HLA | DQA1*0401 |
| EBI-HLA | DQA1*0505 |
| Identifiers | beta 1 *0301 *0302 *0303
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| Symbol(s) | HLA-DQB1 |
| EBI-HLA | DQB1*0301 |
| EBI-HLA | DQB1*0302 |
| EBI-HLA | DQB1*0303 |
| Shared data | |
| Locus | chr.6 6p21.31 |
Within molecular and cell biology, HLA-DQ3 (DQ3) is a broad serotype category with split antigens HLA-DQ7, DQ8, and DQ9. Historically, originally recognized as MB3[1] a DC4 serotype, DQw3 was one of three early determined antigens recognized as HLA-DQ along with HLA-DQ1 and HLA-DQ2.[2] While the DQ3 molecules are structurally similar in beta chain, the DQ molecules differ markedly in function, even when present with the same DQ alpha subunit. For this reason they are best treated independently.
- ^ Goyert SM, Silver J (1983). "Further characterization of HLA-DS molecules: implications for studies assessing the role of human Ia molecules in cell interactions and disease susceptibility". Proc. Natl. Acad. Sci. U.S.A. 80 (18): 5719–23. Bibcode:1983PNAS...80.5719G. doi:10.1073/pnas.80.18.5719. PMC 384330. PMID 6193521.
- ^ Möller E, Carlsson B, Wallin J (1985). "Implication of structural class II gene polymorphism for the concept of serologic specificities". Immunol. Rev. 85: 107–28. doi:10.1111/j.1600-065X.1985.tb01132.x. PMID 2412948. S2CID 20971131.