HLA-DQB1

HLA-DQB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JK8, 1S9V, 1UVQ, 2NNA, 4GG6
Identifiers
Aliases	HLA-DQB1, CELIAC1, HLA-DQB, IDDM1, major histocompatibility complex, class II, DQ beta 1, HLA-DRB1
External IDs	OMIM: 604305; MGI: 103070; HomoloGene: 1603; GeneCards: HLA-DQB1; OMA:HLA-DQB1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,668,383 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,488,393 bp
RNA expression pattern
	Top expressed in
	right lung; ; spleen; ; upper lobe of left lung; ; gallbladder; ; lymph node; ; monocyte; ; granulocyte; ; right coronary artery; ; rectum; ; visceral pleura;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; thymus; ; submandibular gland; ; skin of external ear; ; right lung lobe; ; lip; ; white adipose tissue; ; right kidney; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptide antigen binding; MHC class II receptor activity; protein binding;
Cellular component	integral component of membrane; endocytic vesicle membrane; clathrin-coated endocytic vesicle membrane; endosome; Golgi apparatus; trans-Golgi network membrane; endoplasmic reticulum membrane; membrane; Golgi membrane; plasma membrane; transport vesicle membrane; MHC class II protein complex; lysosomal membrane; endoplasmic reticulum; ER to Golgi transport vesicle membrane; lysosome; integral component of lumenal side of endoplasmic reticulum membrane; endosome membrane;
Biological process	antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; interferon-gamma-mediated signaling pathway; immunoglobulin production involved in immunoglobulin-mediated immune response; immune system process; T cell costimulation; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; humoral immune response mediated by circulating immunoglobulin; immune response; T cell receptor signaling pathway; adaptive immune response;
	Sources:Amigo / QuickGO
Orthologs
	3119
	14961
ENSG00000233209; ENSG00000206237; ENSG00000231286; ENSG00000206302; ENSG00000179344;
	ENSG00000231939; ENSG00000225824
	ENSMUSG00000073421
	P01920
P14483; P01921; P06342; P06343; P06345;
	P06346
	NM_002123; NM_001243961; NM_001243962
	NM_207105
	NP_001230890; NP_001230891; NP_002114
	NP_996988
	Wikidata
View/Edit Human	View/Edit Mouse

Major histocompatibility complex, class II, DQ beta 1, also known as HLA-DQB1, is a human gene and also denotes the genetic locus that contains this gene.^[5] The protein encoded by this gene is one of two proteins that are required to form the DQ heterodimer, a cell surface receptor essential to the function of the immune system.

^ ^a ^b ^c ENSG00000206237, ENSG00000231286, ENSG00000206302, ENSG00000179344, ENSG00000231939, ENSG00000225824 GRCh38: Ensembl release 89: ENSG00000233209, ENSG00000206237, ENSG00000231286, ENSG00000206302, ENSG00000179344, ENSG00000231939, ENSG00000225824 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000073421 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: HLA-DQB1 major histocompatibility complex, class II, DQ beta 1".

[refGRCh38Ensembl-1] ENSG00000206237, ENSG00000231286, ENSG00000206302, ENSG00000179344, ENSG00000231939, ENSG00000225824 GRCh38: Ensembl release 89: ENSG00000233209, ENSG00000206237, ENSG00000231286, ENSG00000206302, ENSG00000179344, ENSG00000231939, ENSG00000225824 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000073421 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Entrez_Gene_3119-5] "Entrez Gene: HLA-DQB1 major histocompatibility complex, class II, DQ beta 1".

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