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| DR1 binding pocket with ligand PDB: 2G9H [1] | ||
major histocompatibility complex, class II, DR1
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| Haplotypes groups | DRA*01:DRB1*01:01 DRA*01:DRB1*01:02 DRA*01:DRB1*01:03 | |
| Structure (See HLA-DR) | ||
| Identifiers | alpha *01:01
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| Symbol(s) | HLA-DRA[permanent dead link] | |
| EBI-HLA | DRA *01:01 | |
| Identifiers | beta 1 *01:01, *01:02, *01:03 . . .
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| Symbol(s) | HLA-DRB1[permanent dead link] | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. It has been observed to be common among centenarians.[2][3][4]
- ^ Fernández MM, Guan R, Swaminathan CP, Malchiodi EL, Mariuzza RA (2006). "Crystal structure of staphylococcal enterotoxin I (SEI) in complex with a human major histocompatibility complex class II molecule". J. Biol. Chem. 281 (35): 25356–25364. doi:10.1074/jbc.M603969200. PMC 2730046. PMID 16829512.
- ^ "The genetics of exceptional human longevity".
- ^ Willcox, B. J.; Willcox, D. C.; He, Q.; Curb, J. D.; Suzuki, M. (2006). "Siblings of Okinawan Centenarians Share Lifelong Mortality Advantages". The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 61 (4): 345–354. doi:10.1093/gerona/61.4.345. PMID 16611700.
- ^ Garoyan, Georges (1990). Cent-quatorze ans de vie ou la longue histoire de Jeanne Calment, doyenné d'âge de France [One Hundred and Fourteen Years of Life or the Long History of Jeanne Calment, the Eldest of France]. Marseille: Université d'Aix-Marseille II. pp. 22–42.