HLA-DR52

Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR53
Haplotypes groups DRA*01:DRB3*01 DRA*01:DRB3*02 DRA*01:DRB3*03
Structure (See HLA-DR)
Identifiers
alpha *01:01
Symbol(s) HLA-DRA[permanent dead link]
EBI-HLA DRA*01:01
Identifiers
beta 3 *01 *02 *03
Symbol(s) HLA-DRB3[permanent dead link]
EBI-HLA DRB3*01
EBI-HLA DRB3*02
EBI-HLA DRB3*03 Archived 2011-05-15 at the Wayback Machine
Shared data
Locus chr.6 6p21.31

HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. Three allele groups can produce 35 isoforms.

DRB3, DRB4, and DRB5 are minor DR beta-encoding loci, and they have been recognized as having distinct evolution,[1] having diverged from DRB1 around 4 million years ago.[2]

The DRB3 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB3.

  1. ^ Gorski J, Rollini P, Mach B (1987). "Structural comparison of the genes of two HLA-DR supertypic groups: the loci encoding DRw52 and DRw53 are not truly allelic". Immunogenetics. 25 (6): 397–402. doi:10.1007/BF00396106. PMID 3596674. S2CID 25853147.
  2. ^ Gongora R, Figueroa F, Klein J (1996). "The HLA-DRB9 gene and the origin of HLA-DR haplotypes". Hum. Immunol. 51 (1): 23–31. doi:10.1016/S0198-8859(96)00189-9. PMID 8911994.