HLA-DRA

HLA-DRA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A6A, 1AQD, 1BX2, 1D5M, 1D5X, 1D5Z, 1D6E, 1DLH, 1FV1, 1FYT, 1H15, 1HXY, 1J8H, 1JWM, 1JWS, 1JWU, 1KG0, 1KLG, 1KLU, 1LO5, 1PYW, 1R5I, 1SEB, 1SJE, 1SJH, 1T5W, 1T5X, 1YMM, 1ZGL, 2FSE, 2G9H, 2IAM, 2IAN, 2ICW, 2IPK, 2OJE, 2Q6W, 2WBJ, 2XN9, 3C5J, 3L6F, 3O6F, 3PDO, 3PGC, 3PGD, 3QXA, 3QXD, 3S4S, 3S5L, 3T0E, 4AEN, 4AH2, 4E41, 4FQX, 4GBX, 4H1L, 4C56, 4H25, 4H26, 4I5B, 4IS6, 4MCY, 4MCZ, 4MD0, 4MD4, 4MD5, 4MDI, 4MDJ, 4OV5, 4Y19, 4Y1A, 4X5X, 4X5W
Identifiers
Aliases	HLA-DRA, HLA-DRA1, MLRW, major histocompatibility complex, class II, DR alpha
External IDs	OMIM: 142860; MGI: 95900; HomoloGene: 7751; GeneCards: HLA-DRA; OMA:HLA-DRA - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 32,439,878 bp[1] End 32,445,046 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte appendix lymph node granulocyte gallbladder duodenum spleen upper lobe of left lung right lung smooth muscle tissue n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptide antigen binding MHC class II receptor activity MHC class II protein complex binding protein binding Cellular component integral component of membrane endocytic vesicle membrane clathrin-coated endocytic vesicle membrane endosome Golgi apparatus trans-Golgi network membrane endoplasmic reticulum membrane membrane late endosome membrane Golgi membrane plasma membrane transport vesicle membrane integral component of plasma membrane cell surface lysosomal membrane endoplasmic reticulum ER to Golgi transport vesicle membrane lysosome integral component of lumenal side of endoplasmic reticulum membrane endosome membrane extracellular exosome MHC class II protein complex Biological process antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II cognition interferon-gamma-mediated signaling pathway immune system process T cell costimulation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune response peptide antigen assembly with MHC class II protein complex viral process T cell receptor signaling pathway adaptive immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3122 100504404 Ensembl ENSG00000206308 ENSG00000228987 ENSG00000230726 ENSG00000204287 ENSG00000227993 ENSG00000226260 ENSG00000234794 ENSG00000277263 ENSMUSG00000036322 UniProt P01903 P04224 P01904 RefSeq (mRNA) NM_019111 NM_010381 RefSeq (protein) NP_061984 NP_034511 Location (UCSC) Chr 6: 32.44 – 32.45 Mb n/a PubMed search [2] [3]
Wikidata
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HLA class II histocompatibility antigen, DR alpha chain is a protein that in humans is encoded by the HLA-DRA gene.^[4] HLA-DRA encodes the alpha subunit of HLA-DR. Unlike the alpha chains of other Human MHC class II molecules, the alpha subunit is practically invariable. However it can pair with, in any individual, the beta chain from 3 different DR beta loci, DRB1, and two of any DRB3, DRB4, or DRB5 alleles. Thus there is the potential that any given individual can form 4 different HLA-DR isoforms (2 alleles of DRB1 and two alleles from DRB3, DRB4 or DRB5).