HLA-E

HLA-E
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3CII, 1KPR, 1KTL, 1MHE, 2ESV, 3AM8, 3BZE, 3BZF, 3CDG
Identifiers
Aliases	HLA-E, EA1.2, EA2.1, HLA-6.2, MHC, QA1, major histocompatibility complex, class I, E
External IDs	OMIM: 143010; MGI: 2442805; HomoloGene: 134018; GeneCards: HLA-E; OMA:HLA-E - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	30,494,194 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	36,422,550 bp
RNA expression pattern
	Top expressed in
	blood; ; right lung; ; granulocyte; ; upper lobe of left lung; ; monocyte; ; spleen; ; lymph node; ; subcutaneous adipose tissue; ; appendix; ; gallbladder;
	Top expressed in
	thymus; ; intestinal villus; ; granulocyte; ; mesenteric lymph nodes; ; duodenum; ; Paneth cell; ; jejunum; ; zygote; ; right kidney; ; blastocyst;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	beta-2-microglobulin binding; MHC class I protein binding; signaling receptor binding; natural killer cell lectin-like receptor binding; peptide antigen binding; T cell receptor binding;
Cellular component	integral component of membrane; phagocytic vesicle membrane; early endosome membrane; membrane; MHC class Ib protein complex; Golgi membrane; plasma membrane; cell surface; MHC class I protein complex; ER to Golgi transport vesicle membrane; integral component of lumenal side of endoplasmic reticulum membrane; extracellular exosome; recycling endosome membrane;
Biological process	antigen processing and presentation; adaptive immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; CD8-positive, alpha-beta T cell activation; interferon-gamma-mediated signaling pathway; immune system process; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of T cell mediated cytotoxicity; positive regulation of TRAIL production; positive regulation of interleukin-4 production; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; protection from natural killer cell mediated cytotoxicity; positive regulation of interleukin-13 production; type I interferon signaling pathway; immune response; regulation of natural killer cell mediated immunity; positive regulation of natural killer cell mediated immunity; regulation of immune response; positive regulation of tumor necrosis factor production; innate immune response; positive regulation of CD8-positive, alpha-beta T cell proliferation; antigen processing and presentation of endogenous peptide antigen via MHC class Ib;
	Sources:Amigo / QuickGO
Orthologs
	3133
	667803
ENSG00000204592; ENSG00000225201; ENSG00000236632; ENSG00000230254; ENSG00000206493;
	ENSG00000233904; ENSG00000229252
	ENSMUSG00000073405
	P13747
	n/a
	NM_005516
	NM_001271005
	NP_005507
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

HLA class I histocompatibility antigen, alpha chain E (HLA-E) also known as MHC class I antigen E is a protein that in humans is encoded by the HLA-E gene.^[5] The human HLA-E is a non-classical MHC class I molecule that is characterized by a limited polymorphism and a lower cell surface expression than its classical paralogues. The functional homolog in mice is called Qa-1b, officially known as H2-T23.

^ ^a ^b ^c ENSG00000225201, ENSG00000236632, ENSG00000230254, ENSG00000206493, ENSG00000233904, ENSG00000229252 GRCh38: Ensembl release 89: ENSG00000204592, ENSG00000225201, ENSG00000236632, ENSG00000230254, ENSG00000206493, ENSG00000233904, ENSG00000229252 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000073405 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mizuno S, Trapani JA, Koller BH, Dupont B, Yang SY (Jun 1988). "Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene". Journal of Immunology. 140 (11): 4024–30. doi:10.4049/jimmunol.140.11.4024. PMID 3131426.

[refGRCh38Ensembl-1] ENSG00000225201, ENSG00000236632, ENSG00000230254, ENSG00000206493, ENSG00000233904, ENSG00000229252 GRCh38: Ensembl release 89: ENSG00000204592, ENSG00000225201, ENSG00000236632, ENSG00000230254, ENSG00000206493, ENSG00000233904, ENSG00000229252 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000073405 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3131426-5] Mizuno S, Trapani JA, Koller BH, Dupont B, Yang SY (Jun 1988). "Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene". Journal of Immunology. 140 (11): 4024–30. doi:10.4049/jimmunol.140.11.4024. PMID 3131426.

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