HMGB1

HMGB1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2LY4, 2RTU, 2YRQ
Identifiers
Aliases	HMGB1, HMG1, HMG3, SBP-1, HMG-1, high mobility group box 1, HMGB-1
External IDs	OMIM: 163905; HomoloGene: 110676; GeneCards: HMGB1; OMA:HMGB1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.3 Start 30,456,704 bp[1] End 30,617,597 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence Achilles tendon smooth muscle tissue body of uterus appendix trabecular bone rectum C1 segment canal of the cervix n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity bubble DNA binding DNA polymerase binding C-X-C chemokine binding transcription factor binding phosphatidylserine binding lipopolysaccharide binding lyase activity single-stranded DNA binding damaged DNA binding protein binding DNA binding, bending supercoiled DNA binding DNA binding four-way junction DNA binding RAGE receptor binding chemoattractant activity RNA binding double-stranded DNA binding double-stranded RNA binding single-stranded RNA binding cytokine activity calcium-dependent protein kinase regulator activity protein kinase activator activity transcription coactivator activity integrin binding Cellular component cytoplasm endosome membrane transcription repressor complex extracellular region nucleus cell surface plasma membrane nucleoplasm chromosome condensed chromosome endoplasmic reticulum-Golgi intermediate compartment secretory granule lumen ficolin-1-rich granule lumen extracellular space early endosome neuron projection alphav-beta3 integrin-HMGB1 complex Biological process T-helper 1 cell activation apoptotic DNA fragmentation adaptive immune response regulation of transcription by RNA polymerase II positive regulation of DNA ligation positive regulation of JNK cascade cellular response to DNA damage stimulus apoptotic cell clearance positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of toll-like receptor 9 signaling pathway negative regulation of RNA polymerase II transcription preinitiation complex assembly positive regulation of dendritic cell differentiation positive regulation of DNA binding neuron projection development negative regulation of blood vessel endothelial cell migration positive regulation of interleukin-12 production positive regulation of monocyte chemotaxis activation of innate immune response DNA ligation involved in DNA repair innate immune response inflammatory response DNA repair positive regulation of MAPK cascade positive regulation of activated T cell proliferation DNA geometric change DNA recombination inflammatory response to antigenic stimulus positive regulation of interleukin-10 production immune system process negative regulation of transcription by RNA polymerase II regulation of restriction endodeoxyribonuclease activity chemotaxis positive regulation of mismatch repair negative regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of cytosolic calcium ion concentration T-helper 1 cell differentiation dendritic cell chemotaxis autophagy neutrophil clearance V(D)J recombination positive regulation of apoptotic process DNA topological change positive chemotaxis toll-like receptor signaling pathway neutrophil degranulation eye development myeloid dendritic cell activation positive regulation of protein phosphorylation endothelial cell proliferation plasmacytoid dendritic cell activation macrophage activation involved in immune response regulation of tolerance induction regulation of T cell mediated immune response to tumor cell base-excision repair regulation of autophagy lung development activation of protein kinase activity positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of toll-like receptor 2 signaling pathway positive regulation of toll-like receptor 4 signaling pathway endothelial cell chemotaxis positive regulation of innate immune response positive regulation of myeloid cell differentiation positive regulation of glycogen catabolic process regulation of protein kinase activity positive regulation of transcription by RNA polymerase II response to glucocorticoid positive regulation of ERK1 and ERK2 cascade positive regulation of wound healing positive regulation of NIK/NF-kappaB signaling positive regulation of sprouting angiogenesis negative regulation of apoptotic cell clearance regulation of nucleotide-excision repair regulation of signaling receptor activity chromatin remodeling positive regulation of autophagy developmental process positive regulation of blood vessel endothelial cell migration cell chemotaxis cellular response to lipopolysaccharide positive regulation of vascular endothelial cell proliferation negative regulation of interferon-gamma production positive regulation of monocyte chemotactic protein-1 production cellular response to interleukin-7 Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3146 n/a Ensembl ENSG00000189403 n/a UniProt P09429 n/a RefSeq (mRNA) NM_001313892 NM_001313893 NM_002128 n/a RefSeq (protein) NP_001300821 NP_001300822 NP_002119 NP_001350590 NP_001357268 NP_001357269 NP_001357270 NP_001300821.1 NP_001300822.1 NP_002119.1 n/a Location (UCSC) Chr 13: 30.46 – 30.62 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

High mobility group box 1 protein, also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a protein that in humans is encoded by the HMGB1 gene.^[3][4]

HMG-1 belongs to the high mobility group and contains a HMG-box domain.