HMGN

HMGN (High Mobility Group Nucleosome-binding) proteins are members of the broader class of high mobility group (HMG) chromosomal proteins that are involved in regulation of transcription, replication, recombination, and DNA repair.

HMGN1 and HMGN2 (initially designated HMG-14 and HMG-17 respectively) were discovered by E.W. Johns research group in the early 1970s.[1] HMGN3, HMGN4, and HMGN5 were discovered later and are less abundant. HMGNs are nucleosome binding proteins that help in transcription, replication, recombination, and DNA repair. They can also alter the chromatin epigenetic landscape, helping to stabilize cell identity.[2] There is still relatively little known about their structure and function.[1] HMGN proteins are found in all vertebrates, and play a role in chromatin structure and histone modification.[3] HMGNs come in long chains of amino acids, containing around 100 for HMGN1-4, and roughly 200 in HMGN5.[3] Recent research on the HMGN family is focused on their effect on cell identity, and how reduction of HMGNs relates to induced reprogramming of mouse embryonic fibroblasts (MEFs).[2]

  1. ^ a b González-Romero R, Eirín-López JM, Ausió J (January 2015). "Evolution of high mobility group nucleosome-binding proteins and its implications for vertebrate chromatin specialization". Molecular Biology and Evolution. 32 (1): 121–31. doi:10.1093/molbev/msu280. PMC 4271525. PMID 25281808.
  2. ^ a b He B, Deng T, Zhu I, Furusawa T, Zhang S, Tang W, Postnikov Y, Ambs S, Li CC, Livak F, Landsman D, Bustin M (December 2018). "Binding of HMGN proteins to cell specific enhancers stabilizes cell identity". Nature Communications. 9 (1): 5240. Bibcode:2018NatCo...9.5240H. doi:10.1038/s41467-018-07687-9. PMC 6286339. PMID 30532006.
  3. ^ a b Kugler JE, Deng T, Bustin M (July 2012). "The HMGN family of chromatin-binding proteins: dynamic modulators of epigenetic processes". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1819 (7): 652–6. doi:10.1016/j.bbagrm.2012.01.013. PMC 3371129. PMID 22326857.