HMS Opossum (1821) was a Cherokee-class brig-sloop launched in 1821 and sold in 1841.
HMS Opossum (1856) was an Albacore-class wooden screw gunboat launched in 1856. She became a hospital hulk in 1876, and a mooring vessel in 1891. She was renamed HMS Siren in 1895 and was sold in 1896.