HRAS

HRAS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras, Harvey rat sarcoma viral oncogene homolog, HRas proto-oncogene, GTPase, RASK2
External IDsOMIM: 190020; MGI: 96224; HomoloGene: 55890; GeneCards: HRAS; OMA:HRAS - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001130442
NM_005343
NM_176795
NM_001318054

NM_001130443
NM_001130444
NM_008284

RefSeq (protein)

NP_001123914
NP_001304983
NP_005334
NP_789765

NP_001123915
NP_001123916
NP_032310

Location (UCSC)Chr 11: 0.53 – 0.54 MbChr 7: 140.77 – 140.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GTPase HRas, from "Harvey Rat sarcoma virus", also known as transforming protein p21 is an enzyme that in humans is encoded by the HRAS gene.[5][6] The HRAS gene is located on the short (p) arm of chromosome 11 at position 15.5, from base pair 522,241 to base pair 525,549.[7] HRas is a small G protein in the Ras subfamily of the Ras superfamily of small GTPases. Once bound to Guanosine triphosphate, H-Ras will activate a Raf kinase like c-Raf, the next step in the MAPK/ERK pathway.

  1. ^ a b c ENSG00000174775 GRCh38: Ensembl release 89: ENSG00000276536, ENSG00000174775Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025499Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wong-Staal F, Dalla-Favera R, Franchini G, Gelmann EP, Gallo RC (Jul 1981). "Three distinct genes in human DNA related to the transforming genes of mammalian sarcoma retroviruses". Science. 213 (4504): 226–8. Bibcode:1981Sci...213..226W. doi:10.1126/science.6264598. PMID 6264598.
  6. ^ Russell MW, Munroe DJ, Bric E, Housman DE, Dietz-Band J, Riethman HC, Collins FS, Brody LC (Jul 1996). "A 500-kb physical map and contig from the Harvey ras-1 gene to the 11p telomere". Genomics. 35 (2): 353–60. doi:10.1006/geno.1996.0367. PMID 8661149.
  7. ^ "Entrez Gene: v-Ha-ras Harvey rat sarcoma viral oncogene homolog".