Hanatoxin

Hanatoxin
SCOP classification[1]
ClassSmall proteins
FoldKnottins (small inhibitors, toxins, lectins)
Superfamilyomega toxin-like
FamilySpider toxins
ProteinHanatoxin (HaTx, HaTx1, HaTx2, κ-TRTX-Gr1a)

Hanatoxin is a toxin found in the venom of the Grammostola spatulata tarantula.[2] The toxin is mostly known for inhibiting the activation of voltage-gated potassium channels, most specifically Kv4.2 and Kv2.1, by raising its activation threshold. [3]

  1. ^ http://supfam.org/SUPERFAMILY/cgi-bin/search.cgi?search_field=hanatoxin, consulted 10th Oct. 2012.
  2. ^ Swartz, K.J.; MacKinnon, R. (1995). "An Inhibitor of the Kv2.1 Potassium Channel Isolated from the Venom of a Chilean Tarantula". Neuron. 15 (4): 941–949. doi:10.1016/0896-6273(95)90184-1. PMID 7576642. S2CID 11188679.
  3. ^ Swartz, K.J.; MacKinnon, R. (1997). "Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites". Neuron. 18 (4): 665–673. doi:10.1016/s0896-6273(00)80306-2. PMID 9136774. S2CID 17929074.