| Handball at the 2010 Central American and Caribbean Games | |
|---|---|
 | |
| Venue | Palacio de Recreación y Deportes and El Mani Pavilion |
| Location | Mayaguez |
| Dates | 18–30 July |
The Handball competition at the 2010 Central American and Caribbean Games was held in Mayagüez, Puerto Rico.
The men's tournament was scheduled to be held from 25–30 July, the women's tournament was scheduled to be held from 18–25 July at the Palacio de Recreación y Deportes, the El Mani Pavilion in El Mani; all in Mayagüez.