| Handball at the 2010 South American Games | |
|---|---|
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| Venue | Coliseo Unidad Deportiva Ditaires Itagüi |
| Dates | March 20–30 |
Handball at the 2010 South American Games in Medellín was held from March 20 to March 30. All games were played at Coliseo Unidad Deportiva Ditaires Itagüi.