Haplogroup N-M231

Haplogroup N
Possible time of origin36,800 [95% CI 34,300–39,300] years before present (YFull[1])

44,700 or 38,300 ybp depending on mutation rate[2]

41,900 [95% CI 40,175-43,591] ybp[3]
Coalescence age21,700 [95% CI 19,500–23,900] ybp (YFull[1])

25,313 [95% CI 21,722–28,956] ybp[3]
Possible place of originNorthern East Asia[4][5]
AncestorNO
Defining mutationsM231
Highest frequenciesNganassan 58%[3]–94.1%,[6] Yakuts 81.8%[7]–94.6%,[8] Khakass (Shirinsky District) 90.2%,[9] Siberian Tatars 33.5% (Zabolotnie 89.5%, Iskero-Tobol 23.5%, Tatar-Bukharans 16.5%, Yalutorov 16.3%, Ishtyak-Tokuz 14.5%[10]), Ugrians 77.8%[3] (Khanty 64.3%[11]–89.3%,[12] Mansi 76%[12]), Udmurts 77.8%,[3] Khakas 41%[3]–65%,[11] Komi 33.3%[11]–79.5%,[6] Nenets 75%–92.9%[3] (Tundra Nenets 97.9%,[6] Forest Nenets 98.8%[6]), Vepsians 55%,[3] Finns 42.6% (West)[13]–70.9% (East)[13] or approx. 54%[3]–58.8%,[14] Tuvans 27.2–54.5%,[citation needed] Nanai 46.2%[3][15][16] (20% Hezhe in the PRC,[15] 44.6% Nanai in Russia,[3] 83.8% members of the Samar clan in the Gorin area of the Khabarovsk Territory[16]), Karelians 37.1%[5]–53.8%,[13] Arkhangelsk Russians 42.6% (Arkhangelsk 44.3%,[3] Pinega 40.8%[3]), Lithuanians 40.5%[3]–44.5%,[13] Latvians approx. 42% (41.6%,[13] 42.1%,[17] 43.0%[3]), Mari 41.2%,[3] Saami 40%, Chuvash 33.7%[14]–36%,[3] Buryats 34.5% (20.2%,[18] 25.0%,[19] 30.9%,[20] 48.0%[21]>), Koryaks 33.3%,[6] Estonians 30.6%[3]-33.9%,[13] Volga Tatars 27.8%,[3] Teleuts 25.0%,[6] Northern Altaians 21.8% (18.0%[11][22]–24.6%[23]), Pskov Russians 22.7%,[3] Russians 20%[24] Bashkirs 17.3%,[3] Sibe 17.1%[15]–18.0%,[25] Mordvins 12.5% (10%[3]–13.3%[3]), Mongols 11%,[26][20][15][19][27][28] Kalmyks 10.4% (Torguud 3.4%, Derbet 5.1%, Buzava 5.3%, Khoshut 38.2%),[29][28] Manchus 10% (5.8%,[20] 8.1%,[30] 9.1%,[25] 11.6%,[25] 12.5%,[25] 14.3%[15]), Belarusians 9.7%,[3] Central-Southern Russians 9.1% (Tver 13.2%,[31] Kursk 12.5%[31]–13.3%,[3] Belgorod 11.9%,[3] Kostroma 11.8%,[3] Smolensk 7.0%,[3] Voronezh 6.3%,[3] Oryol 5.5%[3]), Ukrainians 9.0%,[3] Southern Altaians 7.1% (4.2%[23]-9.7%[11]), Mulam 7.1%,[32] Sweden 6.8%[14] (0% Västra Götaland, Halland, Malmö, and Jönköping[33] - 19.5% Västerbotten[34]), Han Chinese 6.77% (0% to 21.4%),[25] Koreans 6.58% (4.41% to 12%) 12% Koreans,[35] 6.58% Koreans from KPGP(Korean Genome Project),[36] 6.9% Jeju[19] 6.4% Gochang [37] 6.3% Gangwon [19] 5.7% North Korean [38] 4.8% Gyeongsang,[19] 4.4% Jeolla,[19] 4.2% Chungcheong,[19] 4.0% Seoul,[39] 3.0% Daejeon,[39] 1.8% Seoul-Gyeonggi,[19] Ulchi 5.8%,[40] Tibetans 5.65%,[41] Kazakhs 5.33% [42] (Suan 0%, Qangly 0%, Oshaqty 0%, Jetyru 1.2%, Dulat 1.6%, Argyn 2.0%, Alimuly 2.5%, Ysty 3.5%, Baiuly 3.9%, Alban 4.3%, Qongyrat 7.4%, Qypshaq 10.3%, Jalair 10.9%, Qozha 16.7%, Syrgeli 65.6%), Northern Thai 5.2%,[43] Uyghurs 4.89% (2.8%,[44] 4.8%,[25] 4.99%,[45] 6.0%,[20] 8.6%[15]), Kyrgyz 3.9% (2.8% Kyzylsu,[46] 3.3% Kyzylsu,[47] 4.5% Kyrgyzstan,[27] 10% Urumqi[46]), Vietnamese 3.4%, Japanese 1.9% (0%,[2] 0.8%,[48] 0.9%,[49] 1.7%,[50] 2.5%,[19] 4.3%,[51] 4.8%,[20] 6.4%[15])

Haplogroup N (M231) is a Y-chromosome DNA haplogroup defined by the presence of the single-nucleotide polymorphism (SNP) marker M231.[Phylogenetics 1]

It is most commonly found in males originating from northern Eurasia. It also has been observed at lower frequencies in populations native to other regions, including parts of the Balkans, Central Asia, East Asia, and Southeast Asia.

However, the basal paragroup N* has only been found in populations indigenous to China and Cambodia.[4] Subclades of N-M231 have been found at low levels in Southeast Asia, the Pacific Islands, Southwest Asia and the Balkans. These factors tend to suggest that it originated in East Asia or Southeast Asia.

  1. ^ a b Cite error: The named reference YFull was invoked but never defined (see the help page).
  2. ^ a b Poznik GD, Xue Y, Mendez FL, Willems TF, Massaia A, Wilson Sayres MA, et al. (June 2016). "Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences". Nature Genetics. 48 (6): 593–599. doi:10.1038/ng.3559. PMC 4884158. PMID 27111036.
  3. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae Cite error: The named reference Ilumae2016 was invoked but never defined (see the help page).
  4. ^ a b Cite error: The named reference isogg2016 was invoked but never defined (see the help page).
  5. ^ a b Cite error: The named reference Rootsi-Zhivotovsky-2006 was invoked but never defined (see the help page).
  6. ^ a b c d e f Karafet TM, Osipova LP, Savina OV, Hallmark B, Hammer MF (November 2018). "Siberian genetic diversity reveals complex origins of the Samoyedic-speaking populations". American Journal of Human Biology. 30 (6): e23194. doi:10.1002/ajhb.23194. PMID 30408262.
  7. ^ Fedorova SA, Reidla M, Metspalu E, Metspalu M, Rootsi S, Tambets K, et al. (June 2013). "Autosomal and uniparental portraits of the native populations of Sakha (Yakutia): implications for the peopling of Northeast Eurasia". BMC Evolutionary Biology. 13 (13): 127. Bibcode:2013BMCEE..13..127F. doi:10.1186/1471-2148-13-127. PMC 3695835. PMID 23782551.
  8. ^ Cite error: The named reference Duggan2013 was invoked but never defined (see the help page).
  9. ^ Cite error: The named reference Kharkov2011 was invoked but never defined (see the help page).
  10. ^ A. T. Agdzhoyan, E. V.Balanovska, A. D. Padyukova, D. O. Dolinina, M. A. Kuznetsova, V. V. Zaporozhchenko, R. A. Skhalyaho, S. M. Koshel, M. K. Zhabagin, Y. M. Yusupov, Kh. Kh. Mustafin, M. V. Ulyanova, Z. A. Tychinskih, M. B. Lavryashina, and O. P. Balanovsky (2016), "The Gene Pool of Siberian Tatars: Five Ways of Origin for the Five Subethnic Groups." МОЛЕКУЛЯРНАЯ БИОЛОГИЯ, Volume 50, No. 6, pp. 978–991. DOI: 10.7868/S0026898416060021
  11. ^ a b c d e Cite error: The named reference KharkovDissertation was invoked but never defined (see the help page).
  12. ^ a b Cite error: The named reference Pimenoff2008 was invoked but never defined (see the help page).
  13. ^ a b c d e f Cite error: The named reference Lappalainen2008 was invoked but never defined (see the help page).
  14. ^ a b c Cite error: The named reference Tambets2018 was invoked but never defined (see the help page).
  15. ^ a b c d e f g Xue et al. 2006
  16. ^ a b Bogunov, Y.V.; Maltseva, O.V.; Bogunova, A.A.; Balanovskaya, E.V. (2015). "The Nanai Clan Samar: The Structure of Gene Pool Based on Y-Chromosome Markers1". Archaeology, Ethnology and Anthropology of Eurasia. 43 (2): 146–152. doi:10.1016/j.aeae.2015.09.015.
  17. ^ Pliss L, Timša L, Rootsi S, Tambets K, Pelnena I, Zole E, et al. (November 2015). "Y-Chromosomal Lineages of Latvians in the Context of the Genetic Variation of the Eastern-Baltic Region". Annals of Human Genetics. 79 (6): 418–430. doi:10.1111/ahg.12130. PMID 26411886. S2CID 13050610.
  18. ^ Derenko M, Malyarchuk B, Denisova GA, Wozniak M, Dambueva I, Dorzhu C, et al. (January 2006). "Contrasting patterns of Y-chromosome variation in South Siberian populations from Baikal and Altai-Sayan regions". Human Genetics. 118 (5): 591–604. doi:10.1007/s00439-005-0076-y. PMID 16261343. S2CID 23011845.
  19. ^ a b c d e f g h i Kim SH, Kim KC, Shin DJ, Jin HJ, Kwak KD, Han MS, et al. (April 2011). "High frequencies of Y-chromosome haplogroup O2b-SRY465 lineages in Korea: a genetic perspective on the peopling of Korea". Investigative Genetics. 2 (1): 10. doi:10.1186/2041-2223-2-10. PMC 3087676. PMID 21463511.
  20. ^ a b c d e Cite error: The named reference Hammer-Karafet2006 was invoked but never defined (see the help page).
  21. ^ Kharkov, V. N.; Khamina, K. V.; Medvedeva, O. F.; Simonova, K. V.; Eremina, E. R.; Stepanov, V. A. (2014). "Gene pool of Buryats: Clinal variability and territorial subdivision based on data of Y-chromosome markers". Russian Journal of Genetics. 50 (2): 180–190. doi:10.1134/S1022795413110082. ISSN 1022-7954. S2CID 15595963.
  22. ^ Khar'kov et al. 2007
  23. ^ a b Dulik MC, Zhadanov SI, Osipova LP, Askapuli A, Gau L, Gokcumen O, et al. (February 2012). "Mitochondrial DNA and Y chromosome variation provides evidence for a recent common ancestry between Native Americans and Indigenous Altaians". American Journal of Human Genetics. 90 (2): 229–246. doi:10.1016/j.ajhg.2011.12.014. PMC 3276666. PMID 22281367.
  24. ^ Malyarchuk et al. 2004
  25. ^ a b c d e f Zhong H, Shi H, Qi XB, Duan ZY, Tan PP, Jin L, et al. (January 2011). "Extended Y chromosome investigation suggests postglacial migrations of modern humans into East Asia via the northern route". Molecular Biology and Evolution. 28 (1): 717–727. doi:10.1093/molbev/msq247. PMID 20837606.
  26. ^ Katoh et al. 2005
  27. ^ a b Di Cristofaro J, Pennarun E, Mazières S, Myres NM, Lin AA, Temori SA, et al. (2013). "Afghan Hindu Kush: where Eurasian sub-continent gene flows converge". PLOS ONE. 8 (10): e76748. Bibcode:2013PLoSO...876748D. doi:10.1371/journal.pone.0076748. PMC 3799995. PMID 24204668.
  28. ^ a b Cite error: The named reference Balinova2019 was invoked but never defined (see the help page).
  29. ^ Cite error: The named reference Malyarchuk2013 was invoked but never defined (see the help page).
  30. ^ Zhang X, He G, Li W, Wang Y, Li X, Chen Y, et al. (2021). "Genomic Insight Into the Population Admixture History of Tungusic-Speaking Manchu People in Northeast China". Frontiers in Genetics. 12: 754492. doi:10.3389/fgene.2021.754492. PMC 8515022. PMID 34659368.
  31. ^ a b Cite error: The named reference Mirabal2009 was invoked but never defined (see the help page).
  32. ^ Wang XQ, Wang CC, Deng QY, Li H (February 2013). "[Genetic analysis of Y chromosome and mitochondrial DNA poly-morphism of Mulam ethnic group in Guangxi, China]". Yi Chuan = Hereditas (in Chinese). 35 (2): 168–74. doi:10.3724/sp.j.1005.2013.00168. PMID 23448929.
  33. ^ Lappalainen T, Hannelius U, Salmela E, von Döbeln U, Lindgren CM, Huoponen K, et al. (January 2009). "Population structure in contemporary Sweden--a Y-chromosomal and mitochondrial DNA analysis". Annals of Human Genetics. 73 (1): 61–73. doi:10.1111/j.1469-1809.2008.00487.x. PMID 19040656. S2CID 205598345.
  34. ^ Karlsson AO, Wallerström T, Götherström A, Holmlund G (August 2006). "Y-chromosome diversity in Sweden - a long-time perspective". European Journal of Human Genetics. 14 (8): 963–970. doi:10.1038/sj.ejhg.5201651. PMID 16724001. S2CID 23227271.
  35. ^ Sun Seong Choi, Kyung Hwa Park, Da Eun Nam, Tae Hoon Kang, Ki Wha Chung, et al., "Y-chromosome haplogrouping for Asians using Y-SNP target sequencing."
  36. ^ Sungwon Jeon, Youngjune Bhak, Yeonsong Choi, et al., "Korean Genome Project: 1094 Korean personal genomes with clinical information." Science Advances 2020; 6 : eaaz7835.
  37. ^ Soon Hee Kim; Byung Won Chun; Jongwoo Jung; Brian M. Kemp; et al. (July 2005). "A preliminary study on the origin of Koreans based on Y-STR variation". International Journal of Legal Medicine. 32 (4): 353–359. doi:10.1007/s13258-010-0030-9. S2CID 7277981.
  38. ^ KS Jeong; HJ Shin; SJ Lee; HS Kim; JY Kim; MS Han; YH Lee; KW Park; BW Chun (2018). "Genetic characteristics of Y-chromosome short tandem repeat haplotypes from cigarette butt samples presumed to be smoked by North Korean men". International Journal of Legal Medicine. 40 (8): 819–824. doi:10.1007/s13258-018-0701-5. PMID 30047114. S2CID 256072306.
  39. ^ a b Park MJ, Lee HY, Yang WI, Shin KJ (July 2012). "Understanding the Y chromosome variation in Korea--relevance of combined haplogroup and haplotype analyses". International Journal of Legal Medicine. 126 (4): 589–599. doi:10.1007/s00414-012-0703-9. PMID 22569803. S2CID 27644576.
  40. ^ Balanovska EV, Bogunov YV, Kamenshikova EN, Balaganskaya OA, Agdzhoyan AT, Bogunova AA, et al. (October 2018). "Demographic and genetic portraits of the Ulchi population". Russian Journal of Genetics. 54 (10): 1245–1253. doi:10.1134/S1022795418100046. S2CID 53085396.
  41. ^ Qi X, Cui C, Peng Y, Zhang X, Yang Z, Zhong H, et al. (August 2013). "Genetic evidence of paleolithic colonization and neolithic expansion of modern humans on the tibetan plateau". Molecular Biology and Evolution. 30 (8): 1761–1778. doi:10.1093/molbev/mst093. PMID 23682168.
  42. ^ Ashirbekov EE, Botbaev DM, Belkozhaev AM, Abayldaev AO, Neupokoeva AS, Mukhataev JE, et al. (2017). "Distribution of Y-Chromosome Haplogroups of the Kazakh from the South Kazakhstan, Zhambyl, and Almaty Regions". Reports of the National Academy of Sciences of the Republic of Kazakhstan. 6 (316): 85–95.
  43. ^ Brunelli A, Kampuansai J, Seielstad M, Lomthaisong K, Kangwanpong D, Ghirotto S, Kutanan W (2017). "Y chromosomal evidence on the origin of northern Thai people". PLOS ONE. 12 (7): e0181935. Bibcode:2017PLoSO..1281935B. doi:10.1371/journal.pone.0181935. PMC 5524406. PMID 28742125.
  44. ^ Shuhu LI, Yilihamu NI, Bake RA, Bupatima AB, Matyusup DO (March 2018). "A study of genetic diversity of three isolated populations in Xinjiang using Y-SNP". Acta Anthropologica Sinica. 37 (1): 146–156.
  45. ^ Yan L (2011). 中国西部人群的遗传混合 [Genetic Mixture of Populations in Western China.] (Ph.D. thesis) (in Chinese). Shanghai: Fudan University. pp. 1–84.
  46. ^ a b Wen SQ, Du PX, Sun C, Cui W, Xu YR, Meng HL, et al. (March 2022). "Dual origins of the Northwest Chinese Kyrgyz: the admixture of Bronze age Siberian and Medieval Niru'un Mongolian Y chromosomes". Journal of Human Genetics. 67 (3): 175–180. doi:10.1038/s10038-021-00979-x. PMID 34531527. S2CID 237546416.
  47. ^ Guo Y, Xia Z, Cui W, Chen C, Jin X, Zhu B (May 2020). "Joint Genetic Analyses of Mitochondrial and Y-Chromosome Molecular Markers for a Population from Northwest China". Genes. 11 (5): 564. doi:10.3390/genes11050564. PMC 7290686. PMID 32443545.
  48. ^ Nonaka, I; Minaguchi, K; Takezaki, N (July 2007). "Y-chromosomal binary haplogroups in the Japanese population and their relationship to 16 Y-STR polymorphisms". Annals of Human Genetics. 71 (4): 480–495. doi:10.1111/j.1469-1809.2006.00343.x. hdl:10130/491. PMID 17274803. S2CID 1041367.
  49. ^ Harayama, Yuta; Kamei, Sayako; Sato, Noriko; Hayashi, Tokutaro; et al. (January 2014). "Analysis of Y chromosome haplogroups in Japanese population using short amplicons and its application in forensic analysis" (PDF). Legal Medicine. 16 (1): 20–25. doi:10.1016/j.legalmed.2013.10.005. hdl:10091/17954. PMID 24262653. S2CID 19534157.
  50. ^ Ochiai, Eriko; Minaguchi, Kiyoshi; Nambiar, Phrabhakaran; Kakimoto, Yu; et al. (September 2016). "Evaluation of Y chromosomal SNP haplogrouping in the HID-Ion AmpliSeq™ Identity Panel". Legal Medicine. 22: 58–61. doi:10.1016/j.legalmed.2016.08.001. PMID 27591541. S2CID 43668117.
  51. ^ Underhill et al. 2000.


Cite error: There are <ref group=Phylogenetics> tags on this page, but the references will not show without a {{reflist|group=Phylogenetics}} template (see the help page).