Heinrich, Duke of Saxe-Merseburg (Merseburg, 2 September 1661 – Doberlug, 28 July 1738), was a duke of Saxe-Merseburg and member of the House of Wettin.
He was the sixth (but fourth surviving) son of Christian I, Duke of Saxe-Merseburg and Christiana of Schleswig-Holstein-Sonderburg-Glücksburg.