Hemangioblast

Hemangioblast
Details
PrecursorMesenchyme (derived from lateral mesoderm)
Identifiers
Latinhemangioblastus
MeSHD055018
THH2.00.04.3.01002
Anatomical terminology

Hemangioblasts are the multipotent precursor cells that can differentiate into both hematopoietic and endothelial cells.[1][2][3] In the mouse embryo, the emergence of blood islands in the yolk sac at embryonic day 7 marks the onset of hematopoiesis. From these blood islands, the hematopoietic cells and vasculature are formed shortly after. Hemangioblasts are the progenitors that form the blood islands. To date, the hemangioblast has been identified in human, mouse and zebrafish[4] embryos.

Hemangioblasts have been first extracted from embryonic cultures and manipulated by cytokines to differentiate along either hematopoietic or endothelial route. It has been shown that these pre-endothelial/pre-hematopoietic cells in the embryo arise out of a phenotype CD34 population. It was then found that hemangioblasts are also present in the tissue of post-natal individuals, such as in newborn infants and adults.

  1. ^ Basak GW, Yasukawa S, Alfaro A, et al. (2009). "Human embryonic stem cells hemangioblast express HLA-antigens". J Transl Med. 7 (1): 27. doi:10.1186/1479-5876-7-27. PMC 2680830. PMID 19386101.
  2. ^ Miki Takeuchi; Yuji Fusei; Mana Watanabe; Christina-Sylvia Andrea; Miho Takeuchi; Hitomi Nakajima; Ken Ohashi; Hiroshi Kaneko; Maki Kobayashi-Osak; Masayuki Yamamoto; Makoto Kobayashia (2015). "LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2". Proceedings of the National Academy of Sciences of the United States of America. 112 (45): 13922–13927. Bibcode:2015PNAS..11213922T. doi:10.1073/pnas.1517326112. PMC 4653156. PMID 26512114.
  3. ^ Hemangioblasts at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  4. ^ Vogeli KM, Jin SW, Martin GR, Stainier DY (September 2006). "A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula". Nature. 443 (7109): 337–9. Bibcode:2006Natur.443..337V. doi:10.1038/nature05045. PMID 16988712. S2CID 4300264.