Hemoglobin, alpha 2

HBA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A00, 1A01, 1A0U, 1A0Z, 1A3N, 1A3O, 1A9W, 1ABW, 1ABY, 1AJ9, 1B86, 1BAB, 1BBB, 1BIJ, 1BUW, 1BZ0, 1BZ1, 1BZZ, 1C7B, 1C7C, 1C7D, 1CLS, 1CMY, 1COH, 1DKE, 1DXT, 1DXU, 1DXV, 1FDH, 1FN3, 1G9V, 1GBU, 1GBV, 1GLI, 1GZX, 1HAB, 1HAC, 1HBA, 1HBB, 1HBS, 1HCO, 1HDB, 1HGA, 1HGB, 1HGC, 1HHO, 1IRD, 1J3Y, 1J3Z, 1J40, 1J41, 1J7S, 1J7W, 1J7Y, 1JY7, 1K0Y, 1K1K, 1KD2, 1LFL, 1LFQ, 1LFT, 1LFV, 1LFY, 1LFZ, 1LJW, 1M9P, 1MKO, 1NEJ, 1NIH, 1NQP, 1O1I, 1O1J, 1O1K, 1O1L, 1O1M, 1O1N, 1O1O, 1O1P, 1QI8, 1QSH, 1QSI, 1QXD, 1QXE, 1R1X, 1R1Y, 1RPS, 1RQ3, 1RQ4, 1RQA, 1RVW, 1SDK, 1SDL, 1SHR, 1SI4, 1THB, 1UIW, 1VWT, 1XXT, 1XY0, 1XYE, 1XZ2, 1XZ4, 1XZ5, 1XZ7, 1XZU, 1XZV, 1Y01, 1Y09, 1Y0A, 1Y0C, 1Y0D, 1Y0T, 1Y0W, 1Y22, 1Y2Z, 1Y31, 1Y35, 1Y45, 1Y46, 1Y4B, 1Y4F, 1Y4G, 1Y4P, 1Y4Q, 1Y4R, 1Y4V, 1Y5F, 1Y5J, 1Y5K, 1Y7C, 1Y7D, 1Y7G, 1Y7Z, 1Y83, 1Y85, 1Y8W, 1YDZ, 1YE0, 1YE1, 1YE2, 1YEN, 1YEO, 1YEQ, 1YEU, 1YEV, 1YFF, 1YG5, 1YGD, 1YGF, 1YH9, 1YHE, 1YHR, 1YIE, 1YIH, 1YVQ, 1YVT, 1YZI, 1Z8U, 2D5Z, 2D60, 2DN1, 2DN2, 2DN3, 2DXM, 2H35, 2HBC, 2HBD, 2HBE, 2HBF, 2HBS, 2HCO, 2HHD, 2HHE, 2M6Z, 2W6V, 2W72, 2YRS, 3B75, 3D17, 3D7O, 3DUT, 3HXN, 3IA3, 3IC0, 3IC2, 3KMF, 3NL7, 3NMM, 3ODQ, 3ONZ, 3OO4, 3OO5, 3OVU, 3P5Q, 3QJB, 3QJC, 3QJD, 3QJE, 3R5I, 3S48, 3S65, 3S66, 3SZK, 3WCP, 3WHM, 4FC3, 4HHB, 4IJ2, 4L7Y, 4M4A, 4M4B, 4MQC, 4MQG, 4MQH, 4MQI, 4MQJ, 4MQK, 4N7N, 4N7O, 4N7P, 4N8T, 4NI0, 4NI1, 4ROL, 4ROM, 4WJG, 4X0L, 4XS0, 6HBW, 5E29, 5E6E, 5EE4, 5HU6, 5JDO, 5KDQ, 5E83,%%s1Y01, 1Z8U, 1BZ1
Identifiers
Aliases	HBA2, HBA-T2, HBH, Hemoglobin, alpha 2, hemoglobin subunit alpha 2, ECYT7
External IDs	OMIM: 141850; MGI: 96015; HomoloGene: 469; GeneCards: HBA2; OMA:HBA2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	173,710 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	32,234,465 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; bone marrow; ; bone marrow cells; ; placenta; ; spleen; ; apex of heart; ; ganglionic eminence; ; muscle of thigh; ; olfactory zone of nasal mucosa;
	Top expressed in
	bone marrow; ; spleen; ; lung; ; yolk sac; ; neural tube; ; mesencephalon; ; heart; ; cerebellar cortex; ; genital tubercle; ; zone of skin;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; oxygen binding; peroxidase activity; oxygen carrier activity; metal ion binding; protein binding; heme binding; haptoglobin binding; organic acid binding;
Cellular component	cytosol; endocytic vesicle lumen; blood microparticle; membrane; extracellular region; cytosolic small ribosomal subunit; hemoglobin complex; extracellular exosome; haptoglobin-hemoglobin complex; extracellular space;
Biological process	positive regulation of cell death; protein heterooligomerization; oxygen transport; receptor-mediated endocytosis; bicarbonate transport; hydrogen peroxide catabolic process; response to hydrogen peroxide; cellular oxidant detoxification; transport;
	Sources:Amigo / QuickGO
Orthologs
	3040
	15122
	ENSG00000188536
	ENSMUSG00000069919
	P69905
	Q91VB8
	NM_000517
	NM_008218
	NP_000508; NP_000508.1; NP_000549.1
	NP_001077424
	Wikidata
View/Edit Human	View/Edit Mouse

Hemoglobin, alpha 2^[5] also known as HBA2 is a gene that in humans codes for the alpha globin chain of hemoglobin.^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188536 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000069919 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "HBA2 gene: MedlinePlus Genetics".
^ Liebhaber SA, Goossens MJ, Kan YW (Dec 1980). "Cloning and complete nucleotide sequence of human 5'-alpha-globin gene". Proceedings of the National Academy of Sciences of the United States of America. 77 (12): 7054–8. Bibcode:1980PNAS...77.7054L. doi:10.1073/pnas.77.12.7054. PMC 350439. PMID 6452630.
^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (Apr 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000188536 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000069919 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "HBA2 gene: MedlinePlus Genetics".

[pmid6452630-6] Liebhaber SA, Goossens MJ, Kan YW (Dec 1980). "Cloning and complete nucleotide sequence of human 5'-alpha-globin gene". Proceedings of the National Academy of Sciences of the United States of America. 77 (12): 7054–8. Bibcode:1980PNAS...77.7054L. doi:10.1073/pnas.77.12.7054. PMC 350439. PMID 6452630.

[pmid2649166-7] Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (Apr 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.

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