Henry Nichols may refer to:
- Henry E. Nichols (died 1899), U.S. Navy officer and the commander of the Department of Alaska
- Henry F. C. Nichols (1833–1890), American politician
- Henry L. Nichols (1823–1915), American physician and Democratic politician from California
- Hobart Nichols (Henry Hobart Nichols, Jr., 1869–1962), American landscape painter and illustrator