Heparin-binding EGF-like growth factor

HBEGF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XDT, 2M8S
Identifiers
Aliases	HBEGF, DTR, DTS, DTSF, HEGFL, heparin binding EGF like growth factor
External IDs	OMIM: 126150; MGI: 96070; HomoloGene: 1466; GeneCards: HBEGF; OMA:HBEGF - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	140,346,603 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	36,648,858 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; gallbladder; ; mucosa of urinary bladder; ; lower lobe of lung; ; synovial membrane; ; upper lobe of left lung; ; Skeletal muscle tissue of rectus abdominis; ; pericardium; ; skin of thigh; ; apex of heart;
	Top expressed in
	ankle; ; ankle joint; ; decidua; ; muscle of thigh; ; sciatic nerve; ; triceps brachii muscle; ; endothelial cell of lymphatic vessel; ; lumbar subsegment of spinal cord; ; epithelium of lens; ; right lung;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	growth factor activity; heparin binding; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; epidermal growth factor receptor binding;
Cellular component	extracellular region; endocytic vesicle membrane; integral component of membrane; membrane; cell surface; plasma membrane; clathrin-coated endocytic vesicle membrane; integral component of plasma membrane; extracellular space; clathrin-coated vesicle membrane;
Biological process	positive regulation of keratinocyte migration; cell chemotaxis; MAPK cascade; signal transduction; wound healing, spreading of epidermal cells; positive regulation of cell migration; positive regulation of cell growth; muscle organ development; positive regulation of smooth muscle cell proliferation; regulation of heart contraction; negative regulation of elastin biosynthetic process; cell migration; positive regulation of wound healing; epidermal growth factor receptor signaling pathway; ERBB2 signaling pathway; phosphatidylinositol phosphate biosynthetic process; peptidyl-tyrosine phosphorylation; regulation of cell motility; positive regulation of cell population proliferation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of signaling receptor activity; positive regulation of protein kinase B signaling; negative regulation of epidermal growth factor receptor signaling pathway; membrane organization;
	Sources:Amigo / QuickGO
Orthologs
	1839
	15200
	ENSG00000113070
	ENSMUSG00000024486
	Q99075
	Q06186
	NM_001945
	NM_010415
	NP_001936
	NP_034545
	Wikidata
View/Edit Human	View/Edit Mouse

Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene.

HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein. An epidermal growth factor produced by monocytes and macrophages, due to an affinity for heparin is termed HB-EGF. It has been shown to play a role in wound healing, cardiac hypertrophy, and heart development and function.^[5] First identified in the conditioned media of human macrophage-like cells, HB-EGF is an 87-amino acid glycoprotein that displays highly regulated gene expression.^[6] Ectodomain shedding results in the soluble mature form of HB-EGF, which influences the mitogenicity and chemotactic factors for smooth muscle cells and fibroblasts. The transmembrane form of HB-EGF is the unique receptor for diphtheria toxin and functions in juxtacrine signaling in cells. Both forms of HB-EGF participate in normal physiological processes and in pathological processes including tumor progression and metastasis, organ hyperplasia, and atherosclerotic disease.^[7] HB-EGF can bind two locations on cell surfaces: heparan sulfate proteoglycans and EGF-receptors effecting cell-to-cell interactions.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113070 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024486 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nanba D, Higashiyama S (February 2004). "Dual intracellular signaling by proteolytic cleavage of membrane-anchored heparin-binding EGF-like growth factor". Cytokine Growth Factor Rev. 15 (1): 13–9. doi:10.1016/j.cytogfr.2003.10.002. PMID 14746810.
^ Jin K, Mao XO, Sun Y, Xie L, Jin L, Nishi E, Klagsbrun M, Greenberg DA (July 2002). "Heparin-binding epidermal growth factor-like growth factor: hypoxia-inducible expression in vitro and stimulation of neurogenesis in vitro and in vivo". J. Neurosci. 22 (13): 5365–73. doi:10.1523/JNEUROSCI.22-13-05365.2002. PMC 6758221. PMID 12097488.
^ Raab G, Klagsbrun M (December 1997). "Heparin-binding EGF-like growth factor". Biochim. Biophys. Acta. 1333 (3): F179–99. doi:10.1016/S0304-419X(97)00024-3. PMID 9426203.
^ Das SK, Wang XN, Paria BC, Damm D, Abraham JA, Klagsbrun M, Andrews GK, Dey SK (May 1994). "Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation". Development. 120 (5): 1071–83. doi:10.1242/dev.120.5.1071. PMID 8026321.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113070 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024486 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14746810-5] Nanba D, Higashiyama S (February 2004). "Dual intracellular signaling by proteolytic cleavage of membrane-anchored heparin-binding EGF-like growth factor". Cytokine Growth Factor Rev. 15 (1): 13–9. doi:10.1016/j.cytogfr.2003.10.002. PMID 14746810.

[pmid12097488-6] Jin K, Mao XO, Sun Y, Xie L, Jin L, Nishi E, Klagsbrun M, Greenberg DA (July 2002). "Heparin-binding epidermal growth factor-like growth factor: hypoxia-inducible expression in vitro and stimulation of neurogenesis in vitro and in vivo". J. Neurosci. 22 (13): 5365–73. doi:10.1523/JNEUROSCI.22-13-05365.2002. PMC 6758221. PMID 12097488.

[pmid9426203-7] Raab G, Klagsbrun M (December 1997). "Heparin-binding EGF-like growth factor". Biochim. Biophys. Acta. 1333 (3): F179–99. doi:10.1016/S0304-419X(97)00024-3. PMID 9426203.

[pmid8026321-8] Das SK, Wang XN, Paria BC, Damm D, Abraham JA, Klagsbrun M, Andrews GK, Dey SK (May 1994). "Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation". Development. 120 (5): 1071–83. doi:10.1242/dev.120.5.1071. PMID 8026321.

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