Hepatitis C virus nonstructural protein 5A

HCV genome

Nonstructural protein 5A (NS5A) is a zinc-binding and proline-rich hydrophilic phosphoprotein that plays a key role in Hepatitis C virus RNA replication.[1][2] It appears to be a dimeric form without trans-membrane helices.[3]

  1. ^ Belda, O; Targett-Adams, P (2012). "Small molecule inhibitors of the hepatitis C virus-encoded NS5A protein". Virus Research. 170 (1–2): 1–14. doi:10.1016/j.virusres.2012.09.007. PMID 23009750.
  2. ^ Huang, Y; Staschke, K; De Francesco, R; Tan, SL (2007). "Phosphorylation of hepatitis C virus NS5A nonstructural protein: A new paradigm for phosphorylation-dependent viral RNA replication?". Virology. 364 (1): 1–9. doi:10.1016/j.virol.2007.01.042. hdl:2434/662845. PMID 17400273.
  3. ^ MacDonald, A; Harris, M (2004). "Hepatitis C virus NS5A: Tales of a promiscuous protein". The Journal of General Virology. 85 (Pt 9): 2485–502. doi:10.1099/vir.0.80204-0. PMID 15302943.