Hepcidin

HAMP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHAMP, HEPC, HFE2B, LEAP1, PLTR, hepcidin antimicrobial peptide
External IDsOMIM: 606464; MGI: 2153530; HomoloGene: 81623; GeneCards: HAMP; OMA:HAMP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021175

NM_183257

RefSeq (protein)

NP_066998

NP_899080

Location (UCSC)Chr 19: 35.28 – 35.29 MbChr 7: 30.62 – 30.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Hepcidin
Solution structure of hepcidin-25.[5]
Identifiers
SymbolHepcidin
PfamPF06446
InterProIPR010500
SCOP21m4f / SCOPe / SUPFAM
OPM superfamily153
OPM protein1m4e
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
hepcidin antimicrobial peptide
Identifiers
SymbolHAMP
NCBI gene57817
HGNC15598
OMIM606464
RefSeqNM_021175
UniProtP81172
Other data
LocusChr. 19 q13.1
Search for
StructuresSwiss-model
DomainsInterPro

Hepcidin is a protein that in humans is encoded by the HAMP gene. Hepcidin is a key regulator of the entry of iron into the circulation in mammals.[6]

During conditions in which the hepcidin level is abnormally high, such as inflammation, serum iron falls due to iron trapping within macrophages and liver cells and decreased gut iron absorption. This typically leads to anemia due to an inadequate amount of serum iron being available for developing red blood cells. When the hepcidin level is abnormally low such as in hemochromatosis, iron overload occurs due to increased ferroportin mediated iron efflux from storage and increased gut iron absorption.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105697Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056978Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ PDB: 1M4F​; Hunter HN, Fulton DB, Ganz T, Vogel HJ (October 2002). "The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis". The Journal of Biological Chemistry. 277 (40): 37597–37603. doi:10.1074/jbc.M205305200. PMID 12138110.
  6. ^ Ganz T (August 2003). "Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation". Blood. 102 (3): 783–788. doi:10.1182/blood-2003-03-0672. PMID 12663437.