High-dose estrogen therapy (HDE) is a type of hormone therapy in which high doses of estrogens are given.[1] When given in combination with a high dose of progestogen, it has been referred to as pseudopregnancy.[2][3][4][5] It is called this because the estrogen and progestogen levels achieved are in the range of the very high levels of these hormones that occur during pregnancy.[6] HDE and pseudopregnancy have been used in medicine for a number of hormone-dependent indications, such as breast cancer, prostate cancer, and endometriosis, among others.[1][7][2] Both natural or bioidentical estrogens and synthetic estrogens have been used and both oral and parenteralroutes may be used.[8][9]
^Ulrich U, Pfeifer T, Lauritzen C (September 1994). "Rapid increase in lumbar spine bone density in osteopenic women by high-dose intramuscular estrogen-progestogen injections. A preliminary report". Hormone and Metabolic Research. 26 (9): 428–31. doi:10.1055/s-2007-1001723. PMID7835827. S2CID260169203.
^Ulrich U, Pfeifer T, Buck G, Keckstein J, Lauritzen C (1995). "High-dose estrogen-progestogen injections in gonadal dysgenesis, ovarian hypoplasia, and androgen insensitivity syndrome: Impact on bone density". Adolescent and Pediatric Gynecology. 8 (1): 20–23. doi:10.1016/S0932-8610(12)80156-3. ISSN0932-8610.