High plains disease is a viral disease afflicting wheat and maize. It is caused by the negative-sense ssRNA virus High Plains wheat mosaic emaravirus. Symptoms are similar to Wheat streak mosaic virus, with leaf veins showing yellow flecks and streaks, followed by leaf margin purpling in maize.[1] Depending on the timing of infection, stunting and death occur. Plants can be doubly infected with high plains virus and wheat streak mosaic virus.