Hisham ibn Isma'il al-Makhzumi (Arabic: هشام بن إسماعيل المخزومي, romanized: Hishām ibn Ismāʿīl al-Makhzūmī) was an 8th-century official of the Umayyad Caliphate, and the maternal grandfather of Caliph Hisham ibn Abd al-Malik. He served as the governor of Medina from 701 to 706.