Histamine H2 receptor

HRH2
Identifiers
Aliases	HRH2, H2R, histamine receptor H2, HH2R
External IDs	OMIM: 142703; MGI: 108482; HomoloGene: 40613; GeneCards: HRH2; OMA:HRH2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	175,710,756 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	54,390,199 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; left ventricle; ; apex of heart; ; body of stomach; ; putamen; ; caudate nucleus; ; myocardium of left ventricle; ; prefrontal cortex;
	Top expressed in
	granulocyte; ; internal carotid artery; ; epithelium of stomach; ; mucous cell of stomach; ; primary visual cortex; ; superior frontal gyrus; ; neuron; ; blood; ; decidua; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; histamine receptor activity; G protein-coupled serotonin receptor activity; neurotransmitter receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; dendrite;
Biological process	visual learning; epithelial cell morphogenesis; gastric acid secretion; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; memory; toxin transport; regulation of synaptic plasticity; gastrin-induced gastric acid secretion; positive regulation of vasoconstriction; immune response; digestive tract development; signal transduction; gland development; histamine-induced gastric acid secretion; G protein-coupled receptor signaling pathway; chemical synaptic transmission; G protein-coupled serotonin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3274
	15466
	ENSG00000113749
	ENSMUSG00000034987
	P25021
	P97292
	NM_001131055; NM_022304; NM_001367711; NM_001393460; NM_001393461
	NM_001010973; NM_008286
	NP_001124527; NP_001354640
	NP_001010973
	Wikidata
View/Edit Human	View/Edit Mouse

H₂ receptors are a type of histamine receptor found in many parts of the anatomy of humans and other animals. They are positively coupled to adenylate cyclase via G_s alpha subunit. It is a potent stimulant of cAMP production, which leads to activation of protein kinase A.^[5] PKA functions to phosphorylate certain proteins, affecting their activity. The drug betazole is an example of a histamine H₂ receptor agonist.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113749 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034987 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference PR1997 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113749 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034987 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[PR1997-5] Cite error: The named reference PR1997 was invoked but never defined (see the help page).

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