| Histidinol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.23 | ||||||||
| CAS no. | 9028-27-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| Histidinol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 the l-histidinol dehydrogenase (hisd) structure implicates domain swapping and gene duplication. | |||||||||
| Identifiers | |||||||||
| Symbol | Histidinol_dh | ||||||||
| Pfam | PF00815 | ||||||||
| Pfam clan | CL0099 | ||||||||
| InterPro | IPR012131 | ||||||||
| PROSITE | PDOC00534 | ||||||||
| SCOP2 | 1k75 / SCOPe / SUPFAM | ||||||||
| |||||||||
In enzymology, histidinol dehydrogenase (HIS4) (HDH) (EC 1.1.1.23) is an enzyme that catalyzes the chemical reaction
- L-histidinol + 2 NAD+ L-histidine + 2 NADH + 2 H+
Thus, the two substrates of this enzyme are L-histidinol and NAD+, whereas its 3 products are L-histidine, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-histidinol:NAD+ oxidoreductase. This enzyme is also called L-histidinol dehydrogenase.