Histone H3

H3 histone, family 3A (H3.3A)
Identifiers
SymbolH3F3A
Alt. symbolsH3F3
NCBI gene3020
HGNC4764
OMIM601128
RefSeqNM_002107
UniProtQ66I33
Other data
LocusChr. 1 q41
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StructuresSwiss-model
DomainsInterPro
H3 histone, family 3B (H3.3B)
Identifiers
SymbolH3F3B
NCBI gene3021
HGNC4765
OMIM601058
RefSeqNM_005324
UniProtP84243
Other data
LocusChr. 17 q25
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StructuresSwiss-model
DomainsInterPro
Basic units of chromatin structure

Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells.[1][2] Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. Histone proteins are highly post-translationally modified however Histone H3 is the most extensively modified of the five histones. The term "Histone H3" alone is purposely ambiguous in that it does not distinguish between sequence variants or modification state. Histone H3 is an important protein in the emerging field of epigenetics, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes.

  1. ^ Bhasin M, Reinherz EL, Reche PA (2006). "Recognition and classification of histones using support vector machine" (PDF). Journal of Computational Biology. 13 (1): 102–12. doi:10.1089/cmb.2006.13.102. PMID 16472024.
  2. ^ Hartl DL, Freifelder D, Snyder LA (1988). Basic Genetics. Boston: Jones and Bartlett Publishers. ISBN 978-0-86720-090-4.