Compounds that inhibit histone deacetylases
Histone deacetylase inhibitors (HDAC inhibitors , HDACi , HDIs ) are chemical compounds that inhibit histone deacetylases . Since deacetylation of histones produces transcriptionally silenced heterochromatin , HDIs can render chromatin more transcriptionally active and induce epigenomic changes.
HDIs have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptics , such as valproic acid . Since at least 2003 they have been investigated as possible treatments for cancers,[ 1] [ 2] [ 3] [ 4]
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