The history of Brasenose College, Oxford, stretches back to 1509, when Brasenose College was founded on the site of Brasenose Hall. Its name is believed to derive from the name of a bronze knocker that adorned the hall's door. The college was associated with Lancashire and Cheshire, the county origins of its two founders – Sir Richard Sutton and the Bishop of Lincoln, William Smyth – a link that was maintained strongly until the latter half of the nineteenth century. The first principals navigated Brasenose, with its Catholic sympathisers, through the reformation and continuing religious reforms. Most of Brasenose favoured the Royalist side during the English Civil War, although it produced notable generals and clergy on both sides. The library and chapel were completed in the mid-seventeenth century, despite Brasenose suffering continuing financial problems.
The post-1785 period would see an era of prosperity of the college under Principal William Cleaver. The college began to be populated by gentlemen, its income doubling between 1790 and 1810, and academic success considerable. Efforts to reconstruct Brasenose were not completed, however, until the second half of the century with the addition of New Quad between 1886 and 1911. Brasenose's financial position remained secure, although under the tenure of Principal Edward Hartopp Cradock Brasenose's academic record waned greatly, with much of its success focussed on sports – where it excelled most notably in cricket and rowing. The mid-Century Royal Commissions were navigated – although they were opposed in form, their recommendations welcomed including the submission of accounts. The election of Charles Buller Heberden as principal in 1889 led to a reversal in Brasenose's academic failures, although its sporting performance suffered. Heberden was the first lay principal, presiding over an increasingly secular college, opening up the library to undergraduates, instituting an entrance exam for the first time and accepting Rhodes scholarships.
Brasenose lost 115 men in the First World War (including a quarter of the 1913 year), with its undergraduate numbers greatly reduced. Lord Curzon's post-war reforms were successfully instituted. The inter-war period was defined by William Stallybrass, who as fellow and eventual principal (until 1948) dominated college life. Brasenose once again produced top sportsmen – cricketers, rowers, and others. This came at the cost of falling academic standards and poorly performing finances, which would see Stallybrass' authority challenged. He died in a railway accident before he could be forced out, however. After the war, sporting achievements waned (although there were notable exceptions) but academic success did not improve significantly, in what was now one of Oxford's largest colleges.
The 1970s saw considerable social change in Brasenose: the admission of women beginning in 1974, more post-graduate attendees and fewer domestic staff. There was also considerable construction work to ensure that undergraduates could be housed for the entirety of their degree on the main site and on the Frewin site; this task was only completed in 1997 with the opening of the St Cross Building and Frewin extension. Law continued to be a strong subject for Brasenose (following on from Stallybrass, through Principals Barry Nicholas and Herbert Hart) as was the emerging subject of Philosophy, Politics and Economics (PPE), starting with the fellowship of Vernon Bogdanor. Brasenose's finances were secured, and it thus entered the twenty-first century in a good position as regards financial, extracurricular and academic success – the last having significantly recovered from its lows, helped by PPE.