Hormone-sensitive lipase

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Hormone-sensitive lipase (HSL) N-terminus
Hormone-sensitive lipase (HSL) N-terminus
Identifiers
Symbol	HSL_N
Pfam	PF06350
InterPro	IPR010468
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

LIPE
Identifiers
Aliases	LIPE, AOMS4, FPLD6, HSL, LHS, lipase E, hormone sensitive type, REH
External IDs	OMIM: 151750; MGI: 96790; HomoloGene: 3912; GeneCards: LIPE; OMA:LIPE - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	42,427,388 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	25,098,135 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; subcutaneous adipose tissue; ; pericardium; ; right testis; ; left testis; ; inferior ganglion of vagus nerve; ; apex of heart; ; middle frontal gyrus; ; inferior olivary nucleus; ; subthalamic nucleus;
	Top expressed in
	brown adipose tissue; ; lactiferous gland; ; white adipose tissue; ; subcutaneous adipose tissue; ; seminiferous tubule; ; embryo; ; intercostal muscle; ; tunica adventitia of aorta; ; muscle of thigh; ; granulocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	lipase activity; triglyceride lipase activity; hormone-sensitive lipase activity; protein binding; hydrolase activity; protein kinase binding; serine hydrolase activity;
Cellular component	cytoplasm; membrane; lipid droplet; plasma membrane; caveola; cytosol;
Biological process	diacylglycerol catabolic process; steroid metabolic process; lipid metabolism; cholesterol metabolic process; lipid catabolic process; protein phosphorylation; long-chain fatty acid catabolic process; metabolism; triglyceride catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	3991
	16890
	ENSG00000079435
	ENSMUSG00000003123
	Q05469
	P54310
	NM_005357
	NM_001039507; NM_010719
	NP_005348
	NP_001034596; NP_034849
	Wikidata
View/Edit Human	View/Edit Mouse

Hormone-sensitive lipase (EC 3.1.1.79, HSL), also previously known as cholesteryl ester hydrolase (CEH),^[5] sometimes referred to as triacylglycerol lipase, is an enzyme that, in humans, is encoded by the LIPE gene,^[6] and catalyzes the following reaction:

(1) diacylglycerol + H₂O = monoacylglycerol + a carboxylate

(2) triacylglycerol + H₂O = diacylglycerol + a carboxylate

(3) monoacylglycerol + -H₂O = glycerol + a carboxylate

HSL is an intracellular neutral lipase capable of hydrolyzing a variety of esters.^[7] The enzyme has a long and a short form. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000079435 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003123 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Aten RF, Kolodecik TR, Macdonald GJ, Behrman HR (November 1995). "Modulation of cholesteryl ester hydrolase messenger ribonucleic acid levels, protein levels, and activity in the rat corpus luteum". Biology of Reproduction. 53 (5): 1110–7. doi:10.1095/biolreprod53.5.1110. PMID 8527515.
^ Langin D, Laurell H, Holst LS, Belfrage P, Holm C (June 1993). "Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium". Proceedings of the National Academy of Sciences of the United States of America. 90 (11): 4897–901. Bibcode:1993PNAS...90.4897L. doi:10.1073/pnas.90.11.4897. PMC 46620. PMID 8506334.
^ Kraemer FB, Shen WJ (October 2002). "Hormone-sensitive lipase: control of intracellular tri-(di-)acylglycerol and cholesteryl ester hydrolysis". Journal of Lipid Research. 43 (10): 1585–94. doi:10.1194/jlr.R200009-JLR200. PMID 12364542.
^ "Entrez Gene: LIPE lipase, hormone-sensitive".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000079435 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003123 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Aten RF, Kolodecik TR, Macdonald GJ, Behrman HR (November 1995). "Modulation of cholesteryl ester hydrolase messenger ribonucleic acid levels, protein levels, and activity in the rat corpus luteum". Biology of Reproduction. 53 (5): 1110–7. doi:10.1095/biolreprod53.5.1110. PMID 8527515.

[pmid8506334-6] Langin D, Laurell H, Holst LS, Belfrage P, Holm C (June 1993). "Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium". Proceedings of the National Academy of Sciences of the United States of America. 90 (11): 4897–901. Bibcode:1993PNAS...90.4897L. doi:10.1073/pnas.90.11.4897. PMC 46620. PMID 8506334.

[pmid12364542-7] Kraemer FB, Shen WJ (October 2002). "Hormone-sensitive lipase: control of intracellular tri-(di-)acylglycerol and cholesteryl ester hydrolysis". Journal of Lipid Research. 43 (10): 1585–94. doi:10.1194/jlr.R200009-JLR200. PMID 12364542.

[entrez-8] "Entrez Gene: LIPE lipase, hormone-sensitive".

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