Horo Guduru Welega (Oromo: Walllaga Horroo Guduruu) is a zone in Oromia Region of Ethiopia. It is named after the former province of Welega, whose eastern part lay in the area Horo Guduru Welega now occupies. Horo Guduru Welega was formed of woredas, including East Welega Zone.
The seat of the zonal administration cabinet is in Shambu town. Shambu is a seat for Horro Woreda and Shambu town woreda in addition to the zonal service.
In this zone, various community associations are working on supporting elderly, children, and youths suffering financially and lacking family support. One such association is Oda Buluq Integrated Development Association (OBIDA), registered in the Federal Democratic Republic of Ethiopia.