| Hsp70 protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of the ATPase fragment of a 70K heat-shock cognate protein.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | HSP70 | ||||||||
| Pfam | PF00012 | ||||||||
| Pfam clan | CL0108 | ||||||||
| InterPro | IPR013126 | ||||||||
| PROSITE | PDOC00269 | ||||||||
| SCOP2 | 3hsc / SCOPe / SUPFAM | ||||||||
| |||||||||
The 70 kilodalton heat shock proteins (Hsp70s or DnaK) are a family of conserved ubiquitously expressed heat shock proteins. Proteins with similar structure exist in virtually all living organisms. Intracellularly localized Hsp70s are an important part of the cell's machinery for protein folding, performing chaperoning functions, and helping to protect cells from the adverse effects of physiological stresses.[2][3] Additionally, membrane-bound Hsp70s have been identified as a potential target for cancer therapies[4] and their extracellularly localized counterparts have been identified as having both membrane-bound and membrane-free structures.[5]
- ^ Flaherty KM, DeLuca-Flaherty C, McKay DB (August 1990). "Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein". Nature. 346 (6285): 623–8. Bibcode:1990Natur.346..623F. doi:10.1038/346623a0. PMID 2143562. S2CID 4338916.
- ^ Tavaria M, Gabriele T, Kola I, Anderson RL (April 1996). "A hitchhiker's guide to the human Hsp70 family". Cell Stress & Chaperones. 1 (1): 23–8. doi:10.1379/1466-1268(1996)001<0023:ahsgtt>2.3.co;2 (inactive 1 November 2024). PMC 313013. PMID 9222585.
{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link) - ^ Morano KA (October 2007). "New tricks for an old dog: the evolving world of Hsp70". Annals of the New York Academy of Sciences. 1113 (1): 1–14. Bibcode:2007NYASA1113....1M. doi:10.1196/annals.1391.018. PMID 17513460. S2CID 20917046.
- ^ Giri B, Sethi V, Modi S, Garg B, Banerjee S, Saluja A, Dudeja V (July 2017). ""Heat shock protein 70 in pancreatic diseases: Friend or foe"". Journal of Surgical Oncology. 116 (1): 114–122. doi:10.1002/jso.24653. PMC 5714583. PMID 28543919.
- ^ De Maio A (May 2014). "Extracellular Hsp70: export and function". Current Protein & Peptide Science. 15 (3): 225–31. doi:10.2174/1389203715666140331113057. PMID 24694368.