Sir Hugh Willoughby (fl. 1544; died 1554) was an English soldier and an early Arctic voyager. He served in the court of Henry VIII and fought in the Scottish campaign where he was knighted for his valour. In 1553, he was selected by a company of London merchants to lead a fleet of three vessels in search of a Northeast Passage.
Willoughby and the crews of two ships died on the voyage while the third vessel Edward Bonaventure, under the command of Richard Chancellor, who went on to open a successful, long-lasting trading arrangement with Russia.