Humanin

MT-RNR2
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesRNR2, mitochondrially encoded 16S RNA, MTRNR2
External IDsOMIM: 561010; MGI: 102492; GeneCards: RNR2; OMA:RNR2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

4550

17725

Ensembl

ENSG00000210082

ENSMUSG00000064339

UniProt

Q8IVG9

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse
The humanin gene is found within the 16S rRNA gene (MT-RNR2) in the mitochondrial genome

Humanin is a micropeptide encoded in the mitochondrial genome by the 16S ribosomal RNA gene, MT-RNR2. Its structure contains a three-turn α-helix, and no symmetry.

In in vitro and animal models, it appears to have cytoprotective effects.[3][4][5][6]

  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Cai H, Liu Y, Men H, Zheng Y (2021). "Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases". Frontiers in Endocrinology. 12: 683151. doi:10.3389/fendo.2021.683151. PMC 8222669. PMID 34177809.
  4. ^ Conte M, Martucci M, Franceschi C, Salvioli S (2020). "Mitochondria, immunosenescence and inflammaging: a role for mitokines?". Seminars in Immunopathology. 42 (5): 607–617. doi:10.1007/s00281-020-00813-0. PMC 7666292. PMID 32757036.
  5. ^ Miller B, Kim S, Cohen P (2022). "Mitochondria-derived peptides in aging and healthspan". Journal of Clinical Investigation. 132 (9): e158449. doi:10.1172/JCI158449. PMC 9057581. PMID 35499074.
  6. ^ Burtscher J, Soltany A, Khamoui AV (2023). "Mitochondrial stress and mitokines in aging". Aging Cell. 22 (2): e13770. doi:10.1111/acel.13770. PMC 9924952. PMID 36642986.