| Hyaluronan synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Chlorella virus hyaluronan synthase with the manganese ion shown as a cyan sphere.[1] | |||||||||
| Identifiers | |||||||||
| EC no. | 2.4.1.212 | ||||||||
| CAS no. | 39346-43-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Hyaluronan synthases (HAS) are membrane-bound enzymes that use UDP-α-N-acetyl-D-glucosamine and UDP-α-D-glucuronate as substrates to produce the glycosaminoglycan hyaluronan at the cell surface and extrude it through the membrane into the extracellular space.
- ^ Maloney, Finn P.; Kuklewicz, Jeremi; Corey, Robin A.; Bi, Yunchen; Ho, Ruoya; Mateusiak, Lukasz; Pardon, Els; Steyaert, Jan; Stansfeld, Phillip J.; Zimmer, Jochen (7 April 2022). "Structure, substrate recognition and initiation of hyaluronan synthase". Nature. 604 (7904): 195–201. Bibcode:2022Natur.604..195M. doi:10.1038/s41586-022-04534-2. PMC 9358715. PMID 35355017.