Hydrogel dressing

Not to be confused with Hydrocolloid dressing.

Hydrogel dressing is a medical dressing based on hydrogels, three-dimensional hydrophilic structure.[1] The insoluble hydrophilic structures absorb polar wound exudates and allow oxygen diffusion at the wound bed to accelerate healing.[2] Hydrogel dressings can be designed to prevent bacterial infection, retain moisture, promote optimum adhesion to tissues, and satisfy the basic requirements of biocompatibility.[1][2] Hydrogel dressings can also be designed to respond to changes in the microenvironment at the wound bed.[3] Hydrogel dressings should promote an appropriate microenvironment for angiogenesis, recruitment of fibroblasts, and cellular proliferation.[2][4]

Hydrogels respond elastically to applied stress; gels made from materials like collagen exhibit high toughness and low sliding friction, reducing damage from mechanical stress.[1][5] Hydrogel dressings should possess mechanical and physical properties similar to the 3D microenvironment of the extracellular matrix of human skin.[6] Hydrogel wound dressings are designed to have a mechanism for application and removal which minimizes further trauma to tissues.[1]

Hydrogel dressings can be sorted into three categories: synthetic, natural, and hybrid.[1] Synthetic hydrogel dressings have been produced using biomimetic extracellular matrix nanofibers such as polyvinyl alcohol (PVA).[7] Self-assembling designer peptide hydrogels are another type of synthetic hydrogel in development.[8] Natural hydrogel dressings are further subdivided into either polysaccharide-based (e.g. alginates) or proteoglycan- and/or protein-based (e.g. collagen).[7] Hybrid hydrogel dressings incorporate synthetic nanoparticles and natural materials.[2]

  1. ^ a b c d e Peppas, N. A.; Hilt, J. Z.; Khademhosseini, A.; Langer, R. (2006-06-06). "Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology". Advanced Materials. 18 (11): 1345–1360. Bibcode:2006AdM....18.1345P. doi:10.1002/adma.200501612. ISSN 0935-9648. S2CID 16865835.
  2. ^ a b c d Tavakoli, Shima; Klar, Agnes S. (2020-08-11). "Advanced Hydrogels as Wound Dressings". Biomolecules. 10 (8): 1169. doi:10.3390/biom10081169. ISSN 2218-273X. PMC 7464761. PMID 32796593.
  3. ^ Ulijn, Rein V.; Bibi, Nurguse; Jayawarna, Vineetha; Thornton, Paul D.; Todd, Simon J.; Mart, Robert J.; Smith, Andrew M.; Gough, Julie E. (April 2007). "Bioresponsive hydrogels". Materials Today. 10 (4): 40–48. doi:10.1016/S1369-7021(07)70049-4.
  4. ^ Percival, Steven L.; McCarty, Sara; Hunt, John A.; Woods, Emma J. (2014-02-24). "The effects of pH on wound healing, biofilms, and antimicrobial efficacy". Wound Repair and Regeneration. 22 (2): 174–186. doi:10.1111/wrr.12125. ISSN 1067-1927. PMID 24611980. S2CID 5393915.
  5. ^ Xu, Cancan; Dai, Guohao; Hong, Yi (September 2019). "Recent advances in high-strength and elastic hydrogels for 3D printing in biomedical applications". Acta Biomaterialia. 95: 50–59. doi:10.1016/j.actbio.2019.05.032. PMC 6710142. PMID 31125728.
  6. ^ Jones, Annie; Vaughan, David (December 2005). "Hydrogel dressings in the management of a variety of wound types: A review". Journal of Orthopaedic Nursing. 9: S1–S11. doi:10.1016/S1361-3111(05)80001-9.
  7. ^ a b Mogoşanu, George Dan; Grumezescu, Alexandru Mihai (March 2014). "Natural and synthetic polymers for wounds and burns dressing". International Journal of Pharmaceutics. 463 (2): 127–136. doi:10.1016/j.ijpharm.2013.12.015. PMID 24368109.
  8. ^ Rivas, Manuel; del Valle, Luís; Alemán, Carlos; Puiggalí, Jordi (2019-03-06). "Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite". Gels. 5 (1): 14. doi:10.3390/gels5010014. ISSN 2310-2861. PMC 6473879. PMID 30845674.